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First pitch for Friday's matchup between the Cardinals and Giants is set for 10:15 PM ET from Oracle Park in San Francisco, CA. The Giants are favored on the money line, with their odds sitting at -130, while the Cardinals' money line odds are at +110. The over/under line is currently 7.5 runs.

This NL matchup features Cardinals pitcher Miles Mikolas and Giants starter Landen Roupp. The Cardinals are 2nd in the NL Central with an overall record of 81-78, while the Giants are 4th in the NL West at 79-80. NBCS will be televising Friday's game.<h3>SAN FRANCISCO GIANTS VS ST. LOUIS CARDINALS BETTING PICK</h3>The Pick: San Francisco Giants Moneyline -130This game will be played at Oracle Park at 10:15 ET on Friday, September 27th.<h3>HOW TO BET THE CARDINALS VS GIANTS:</h3><ul><li>We have the Giants winning by a score of 6 to 5</li><li>However, if you're looking for a run line pick, we like the Cardinals to cover</li><li>As for an over/under pick, we have this game finishing with 11 runs and like the over</li></ul><h3>Cardinals Records & Stats</h3>Led by a big game by Lars Nootbaar at the plate, the Cardinals are coming off a game in which they scored eight runs on 12 hits. However, they still took the loss, as the Rockies scored 10 runs. St. Louis was the slight favorite at -114 on the money line going into the game.

Kyle Gibson had a rough outing, giving up four earned runs on five hits and issuing three walks. The Cardinals also used five relievers, and Ryan Fernandez took the loss out of the bullpen. He only pitched 2/3 of an inning, but the Rockies scored two runs in the bottom of the 8th to take the lead.St. Louis is 81-78 overall and trails the Brewers by 10 games in the NL Central. The Cardinals are 26-26 against other teams in the division. The Cardinals will be on the road today, taking on the Giants, and they are 2-0 as the underdog in their last two games.

At home, the Cardinals are 44-37 this season and 37-41 on the road. They have won three straight series, and their overall series record is 27-20-5 this year. St. Louis has also been good in close games, going 25-17 in one-run games this season.When betting on the run line, the Cardinals have been a better play as the underdog than the favorite, as they are 53-28 against the run line when getting points. They are 40-38 against the run line on the road, and their average run margin in winning games is +2.7, while it's -3.5 in losses.The St. Louis Cardinals are on the road today against the San Francisco Giants. The over/under line for today's game is set at 7.5 runs. The combined run average for Cardinals games this season is 8.6 runs per game. St. Louis has an over/under record of 73-82 this season, and the average over/under line for their games is 8 runs. When the over/under line is set at 7.5 runs, the Cardinals have a record of 13-23. The over/under line has been set at 7.5 runs for 116 of their games this season, accounting for 73.0% of their games. Only 7 of their games have had an over/under line set lower than 7.5 runs, making up just 4.4% of their games.Right-hander Miles Mikolas is starting for the Cardinals today as he faces the Giants on the road. So far this season, he has made 31 starts and has a record of 9-11 with a 5.35 ERA. Looking at his overall numbers, Mikolas has a WHIP of 1.27 and opponents are batting .280 this season. In his 31 appearances, Mikolas has turned in 15 quality starts. Per nine innings, he is averaging 6.37 strikeouts and just 1.3 walks. Mikolas' last outing came on September 21st, where he picked up the win, going six innings and giving up just one earned run. Before that, he had given up at least two earned runs in three straight outings.St. Louis comes into today's game averaging 4.1 runs per game, which is 23rd in the league. As a team, they are batting a collective .246, which is 11th in the MLB. The Cardinals have been led in home runs by Paul Goldschmidt and Alec Burleson, who have 22 and 21 homers, respectively. Brendan Donovan has also been a consistent run producer for the Cardinals, as his 69 RBIs are 3rd in the league.

Over his last five games, Iván Herrera has gone 6/13 with two homers and four RBIs. This has helped him move his season batting average up to .274. Nolan Arenado is also on a five-game hitting streak for the Cardinals. Goldschmidt and Burleson are also near the top of the league in RBIs, as Goldschmidt is 4th and Burleson is 1st.<h3>Giants Records & Stats</h3>The Giants will be looking to get back on track after closing out their series vs. the Diamondbacks with an 8-2 loss. San Francisco was the +212 underdog on the money line going into this matchup. Things started off well for the Giants, as they got on the board with a run in the 2nd inning but gave up the lead right away as the Diamondbacks scored three times in the bottom of the second.

Mason Black got the start for the Giants and took the loss. He only lasted 2 2/3 innings, giving up four earned runs on five hits. The Giants couldn't get anything going offensively after their 2nd inning run, and Heliot Ramos scored the team's other run, going 2/3 at the plate.San Francisco is 79-80 overall, and they are 4th in the NL West, trailing the Dodgers by 16 games. So far, they are 26-26 in divisional games. The Giants will be taking on the Cardinals at home today, and they are 41-37 at home this year.

As the underdog, the Giants are 33-48 this year compared to 46-32 as the favorite. They come into today's game having won three straight as the favorite. The Giants have an overall series record of 25-22-4 and have won three straight series overall. At home, they have dropped four straight series.The Giants have a run line record of 81-78 this season, with an average run margin of 0.0. They are 34-44 against the run line at home, with an average scoring margin of 0.1 per game. When they are favored, they are 33-45 against the run line, but they are 48-33 when they are the underdog.San Francisco is playing at home against the St. Louis Cardinals, and the over/under line for the game is set at 7.5 runs. The Giants have an over/under record of 81-71 this season, and their games have had an average combined run total of 8.6 runs. When the over/under line has been set at 7.5 runs this season, the Giants' games have gone over the total 32 times and under 25 times. Overall, 50.3% of San Francisco's games this season have had over/under lines set higher than 7.5 runs, and the over has hit in their last two games.Giants starter Landen Roupp has made three starts this year and 22 appearances. His record for the season is 1-1, and he has an ERA of 2.70. In his last outing, Roupp picked up the win, going five innings and not giving up a run. He only allowed three hits in that outing. Before that, he had given up at least two earned runs in three straight outings. Opponents are batting .193 off the right-hander this year. Roupp's WHIP for the season is 1.24, and he is averaging 8.29 strikeouts per nine innings.San Francisco's offense has been pretty average this season, averaging 4.3 runs per game (17th in the league). They are also just 16th in team batting average and have an on-base percentage of just .305. The Giants are also just 14th in home runs this season. Over his last five games, Matt Chapman has three homers, but he is just 4/19 in this stretch. Chapman's 27 homers is the best mark on the team and 15th in the league.

Heliot Ramos is also near the top of the Giants' home run leaderboard, as he has 22 homers this season, which is good for 2nd on the team. Ramos has also gone 7/22 in his last five games, including a home run. He is also on a three-game hitting streak. Collectively, the Giants have two of the league's top 15 home run hitters in Chapman and Ramos.