<p>The San Francisco 49ers head to Raymond James Stadium to take on the Tampa Bay Buccaneers in Week 6 of the 2025 NFL season. Both teams come into this game with a record of 4-1. The 49ers have been strong on the road with a perfect 3-0 record away from Levi's Stadium. Head Coach Kyle Shanahan will look to continue their winning ways against a tough opponent.</p> <p>The Buccaneers, led by Head Coach Todd Bowles, have also shown strength this season. Their home record stands at 1-1, and they will aim to improve that in front of their home crowd. The game will take place on Sunday, October 12, 2025, at 4:25 PM and will be broadcast on CBS. Fans can expect a warm day with clear skies, making it a great day for football.</p> <h2>San Francisco 49ers Team Preview</h2> <p>The San Francisco 49ers have shown strong performances this season, winning three out of their first four games. Their recent win against the New Orleans Saints with a score of 26-21 highlighted their passing strength. Mac Jones played a crucial role, throwing for 279 yards and 3 touchdowns.</p> <p>The 49ers have been consistent in their passing game, ranking 4th in the league last season. Christian McCaffrey has been a key player, contributing significantly with both rushing and receiving yards. However, their rushing attack is ranked 12th, indicating room for improvement.</p> <p>Injuries are a concern for the 49ers, with several players on the injured reserve list. Key players like Nick Bosa and George Kittle are out, which could impact their defense and offensive capabilities. The team will need to rely on its depth and adjust strategies to maintain their winning momentum.</p> <h2>49ers vs Buccaneers Game Day Info</h2> <ul><li>Sport: NFL</li><li>Teams: San Francisco 49ers vs. Tampa Bay Buccaneers</li><li>Venue: Raymond James Stadium in Tampa Bay, FL</li><li>Date: Sunday, October 12, 2025</li><li>Betting Odds: 49ers Moneyline +134, Buccaneers Moneyline -159, 49ers Spread +3.0 (-112), Buccaneers Spread -3.0 (-108), Total Over 47.5 (-109), Total Under 47.5 (-111)</li></ul> <h2>Tampa Bay Buccaneers Team Preview</h2> <p>The Tampa Bay Buccaneers have had a strong start this season. They won four out of their first five games. Their latest game was a close win against the Seattle Seahawks, 38-35.</p> <p>Baker Mayfield has been a key player for the Buccaneers. He has thrown for 1,283 yards in five games, ranking fourth in the league. His 10 touchdown passes also put him near the top among quarterbacks.</p> <p>The team has some injuries to watch. Mike Evans is questionable with a hamstring issue. Bucky Irving is doubtful with foot and shoulder problems for the next game.</p> <h2>BTB Betting Pick</h2> <p>The 49ers are given a +3.0 spread at -112 odds. Their defense ranks low in opponent score, allowing 436 points, which is 26th in the league. The Buccaneers, with a strong offense scoring 502 points, are likely to cover the -3.0 spread at -108 odds. The projected score is Buccaneers 28, 49ers 24.</p> <p>The total for this game is set at 47.5. The Buccaneers have a high-scoring offense, while the 49ers' defense has struggled. This suggests a high-scoring game. The recommended pick is to take the over at 47.5 (-109). The projected total score is 52, exceeding the set line.</p>

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