Philadelphia 76ers vs San Antonio Spurs Betting Pick & Prediction 3/21/25

At 8:00 ET, the 76ers (23-46) will travel to San Antonio to take on the Spurs (29-39) in a non-conference matchup. The Spurs are favored by 5.5 points, and the over/under line is set at 240.5.

Philadelphia is currently on a two-game losing streak and is 12th in the Eastern Conference. San Antonio is 13th in the Western Conference and 4th in the Southwest Division.

PHILADELPHIA 76ERS VS SAN ANTONIO SPURS BETTING PICK

The Pick: San Antonio Spurs -5.5

This game will be played at Frost Bank Center at 8:00 ET on Friday, March 21st.

WHY BET THE SAN ANTONIO SPURS:

  • We have this one finishing with a projected score of 89-63 in favor of the Spurs.
  • Our projections have Devin Vassell finishing with 17 points, 4 rebounds and 3 assists.
  • From the field, we have the Spurs finishing with a field goal percentage of 45.8% and knocking down 11 threes.

Can Philadelphia Deliver Being Underdogs on the Road?

Philadelphia’s season record fell to 23-46 after a 133-100 road loss to the Thunder on Wednesday. The 76ers entered the game as +11.5 point underdogs but failed to cover the spread, losing by 33 points. The total points for the game reached 233, exceeding the pre-game O/U line of 227.5 by 5.5 points.

Oklahoma City started the game with a 10-0 run, and Philadelphia couldn’t recover. Although the 76ers won the 2nd quarter 30-28, they were down 103-74 going into the 4th after being outscored 33-18 in the 3rd.

In their 133-100 loss to the Thunder, the 76ers shot just 36.8% from the field. They made 18 threes, but connected at a below-average 31.6% rate from deep.

Quentin Grimes led the way with 28 points, including 10 in the 4th quarter. Justin Edwards added 19, while Chuma Okeke contributed 14 points and 15 rebounds, hitting 4 threes at an 80% clip.

The 76ers struggled defensively against the Thunder, giving up 133 points on Wednesday, including a 42-point 1st quarter. Philadelphia allowed 33 points in the 3rd and 30 in the 4th, as Oklahoma City shot 52% from the field.

Philadelphia also allowed 24 three-pointers on 46% shooting. The Thunder went 15/20 from the free-throw line. The 76ers finished with 29 defensive rebounds, 8 steals, and 3 blocks.

Do the Spurs Have a Shot at a Home Win?

San Antonio improved to 29-39 on the season with a 120-105 win over the Knicks on Wednesday. The Spurs were +8.5 point underdogs but covered the spread with a +15 point victory. The game’s total of 225 points narrowly missed the O/U line of 227.

San Antonio took control early, leading 29-20 after the 1st quarter and going on a 14-0 run to extend their lead from 47-33 to 61-33. The Knicks fought back in the 3rd quarter, outscoring the Spurs 29-16, but San Antonio held on in the 4th, winning the period 37-33.

Sandro Mamukelashvili’s 34-point performance, including 21 in the 4th quarter, led the Spurs to a 120-105 win over the Knicks. He shot 92.9% from the field and hit all 7 of his three-point attempts. Stephon Castle added 22 points, while Chris Paul contributed 12 points and 9 assists.

San Antonio connected on 16 threes, shooting 45.7% from beyond the arc and 50% overall. Mamukelashvili’s 13 points in the 2nd quarter helped the Spurs build momentum, and Chris Paul and Harrison Barnes each scored 10 points in the opening period.

The Spurs put together a strong defensive performance against the Knicks, allowing just 105 points on 42% shooting from the field. San Antonio held New York to 20 points in the 1st quarter and 23 in the 2nd, setting the tone early. Even as the Knicks scored 33 points in the 4th, the Spurs’ defense had already done enough to secure the win.

From beyond the arc, the Spurs limited the Knicks to 11 made threes on 29% shooting. San Antonio also sent New York to the free-throw line 21 times, where they made 16. The Spurs finished with 7 steals and 7 blocks.