Detroit Lions vs Arizona Cardinals Betting Pick & Prediction 9/22/24

The Lions are favored on the road as they take on the Cardinals at 4:25 ET on Sunday, September 22nd. The Lions’ money line odds are -149, while the Cardinals are at +125. The game, which will be televised on FOX, is being played at State Farm Stadium in Glendale, AZ. The Lions are -3 point favorites, and the over/under line is 52.5 points.
DETROIT LIONS VS ARIZONA CARDINALS BETTING PICK
The Pick: Arizona Cardinals +3
This game will be played at State Farm Stadium at 4:25 ET on Sunday, September 22nd.
WHY BET THE ARIZONA CARDINALS:
- We have the Cardinals winning this one by a score of 26 to 25
- Not only do we have the Cardinals winning straight-up, we have them covering the spread at +3
- We see this game finishing below the line of 52.5 points
Will The Lions Pick Up A Win On The Road?
After a 20-16 loss to the Buccaneers, the Lions are now 1-1 on the season. Detroit was favored by -7.5 at home, and with the 4-point loss, they also failed to cover the spread. The combined 36 points was well below the over/under line of 52 points.
The Lions fell behind early, with the Buccaneers leading 6-3 after the 1st quarter and 13-6 at halftime. Detroit fought back in the 3rd quarter, taking a 16-13 lead on a 1-yard touchdown run from David Montgomery. However, Baker Mayfield’s 11-yard touchdown run for Tampa Bay late in the 3rd put the Buccaneers ahead for good.
Detroit’s offense put up 324 yards passing in their 20-16 loss to the Buccaneers, with 26 first downs and 139 yards on the ground. Jared Goff completed 34 of 55 passes for 307 yards, finishing with a passer rating of 61 and throwing two interceptions. Amon-Ra St. Brown led the receiving corps with 119 yards on 11 catches.
Jahmyr Gibbs led the Lions in rushing with 84 yards on 13 attempts, averaging 6.5 yards per attempt and adding 22 receiving yards. Despite their high yardage totals, the Lions failed to score a touchdown through the air and were unable to find the end zone in this game.
In their 20-16 loss to the Buccaneers, the Lions’ defense held the Buccaneers to just 3.0 yards per attempt on 23 rushes. They also limited Tampa Bay to 216 total yards and recorded five sacks. Despite their efforts, the Lions’ offense fell short, managing just 16 points.
Detroit’s defense defended the pass well, allowing only 146 yards through the air on 12 completions. They also picked off one pass and held the Buccaneers to a 20% conversion rate on third down.
Will The Cardinals Win At Home Over The Lions?
Arizona’s 41-10 win over the Rams evened their record at 1-1. The Cardinals jumped out to a 14-0 lead after the 1st quarter and never looked back. They added a touchdown in the 2nd quarter to lead 21-0 and finished the game with a 31-point victory. The over/under line was 47.5 points, and the Cardinals easily surpassed that with a combined 51 points.
James Conner and Kyler Murray had multiple touchdowns in this one. Conner and Murray each had rushing touchdowns in the 3rd quarter, and Murray also threw two touchdowns to Marvin Harrison Jr. in the 1st quarter. Arizona capped off their win with a 2-yard touchdown run from Conner in the 4th quarter.
The Cardinals’ offense put up 41 points in their most recent game, a 41-10 win over the Rams. They had 24 first downs and 231 yards on the ground, averaging 5.8 yards per attempt. Kyler Murray completed 17 of 21 passes for 266 yards and three touchdowns, finishing with a passer rating of 158 and adding 59 yards rushing.
James Conner ran for 122 yards, including a long run of 22 yards, and found the end zone once. Marvin Harrison Jr. had a big game receiving, totaling 130 yards and two touchdowns through the air.
In their most recent game, the Cardinals’ defense was dominant, allowing just 53 rushing yards on 20 attempts and holding the Rams to 10 points in a 41-10 victory. The passing game was also locked down, as Arizona gave up only 192 passing yards and allowed just 19 completions. Opposing quarterbacks completed 70.4% of their passes against the Cardinals, and the Rams converted only 18.2% of their third down attempts.
Arizona’s defense was disruptive up front, recording five sacks and winning the battle in quarterback hits, tackles for loss, and not allowing any passing touchdowns.