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The White Sox and Padres face off in an interleague matchup at 8:40 PM ET on Saturday. This one is being played at PETCO Park in San Diego, and the White Sox are on a three-game losing streak, which has them in 5th place in the AL Central. The Padres are 2nd in the NL West with an overall record of 88-66.</

Chris Flexen will go for the White Sox, while the Padres are starting Martin Perez. San Diego is heavily favored on the money line, with their odds sitting at -272 compared to the White Sox at +226. The over/under line is currently 8 runs, and NBCS will be televising this one.<h3>CHICAGO WHITE SOX VS SAN DIEGO PADRES BETTING PICK</h3>The Pick: OVER 8 RunsThis game will be played at PETCO Park at 8:40 ET on Saturday, September 21st.<h3>HOW TO BET THE WHITE SOX VS PADRES:</h3><ul><li>We have the Padres winning by a score of 6 to 5</li><li>However, if you're looking for a run line pick, we like the White Sox to cover</li><li>As for an over/under pick, we have this game finishing with 11 runs and like the over</li></ul>San Diego picked up a 3-2 win over the White Sox in the most recent game of this series. The Padres had a two-run lead going into the 9th inning, and the White Sox could only muster two runs in the final frame. Heading into the game, the Padres were favored at -296 on the money line.

Joe Musgrove started for the Padres and picked up the win, going six innings and not giving up a run. He finished the game with nine strikeouts but didn't issue a walk. Garrett Crochet only went four innings for the White Sox, giving up one run on one hit.

At the plate, Jake Cronenworth went 3/3 with two runs scored for the Padres. Xander Bogaerts and Jackson Merrill each had two hits and two RBIs. For the White Sox, Lenyn Sosa hit the game's only home run and drove in two runs.<h3>White Sox Records & Stats</h3>With an overall record of 36-118, the White Sox are 53.5 games behind the Guardians for the AL Central lead. Chicago has lost three straight games and is 8-41 against other AL Central teams this year. At home, the White Sox are just 20-58 while going 16-60 on the road.

Chicago has struggled as the underdog this year, going 31-115, but they have been better as the favorite, posting a record of 5-3. So far, the White Sox are 7-41-2 in series this year. They have also struggled in day games, going 13-47 compared to 23-71 in night games. The White Sox lost the series opener vs. the Padres and are just 3-7 in their last 10 games.When the White Sox are on the road, they are 32-44 against the run line this season. Their average run differential is -2.2 runs per game when playing away from Chicago. They have covered the run line in two straight games and are 5-3 against the run line as the favorite this season.The Chicago White Sox are on the road to face the San Diego Padres today. The O/U line is set at 8 runs, and the combined run average for White Sox games this season is 8.2 runs. The White Sox have an O/U record of 65-81 for the season, and their average O/U line is also 8 runs. When the O/U line has been set at 8 runs, their record is 13-14-3. Overall, 50.0% of their games have had O/U lines set at 8 runs. Their current under streak is at 3 games. Right-hander Chris Flexen gets the start for the White Sox today as he faces the Padres on the road. Flexen has made 28 starts this season and has a record of 2-14 with an ERA of 5.08. So far, he has turned in nine quality starts and is coming off an outing in which he didn't allow a run. Against the Athletics on September 14th, Flexen went five innings, giving up six hits and two walks. He finished with eight strikeouts in that outing. Flexen has allowed at least one homer in four straight outings.
Andrew Vaughn and Andrew Benintendi are both tied for the team lead in home runs this season, but they have done so while having two of the worst batting averages in the White Sox lineup. Vaughn is batting .247, while Benintendi is hitting just .226. Vaughn's 67 RBIs are the best on the team, and Benintendi is 2nd with 60 RBIs.

Over his last eight games, Lenyn Sosa is batting .387, and he has two home runs in this stretch. Andrew Benintendi has also been swinging a hot bat of late, going 9/34 in his last nine games, including three homers and seven RBIs. Martin Maldonado and Paul DeJong both have five-game hitting streaks.<h3>Padres Records & Stats</h3>With an overall record of 88-66, the Padres are four games behind the Dodgers for the NL West lead. The Padres have won two straight games, and they are 7-3 across their last 10 games overall. San Diego took the first game of this series vs. the White Sox and have an overall series record of 30-15-6 this year.

At home, the Padres are 43-36 this year and 45-30 on the road. As the favorite, the Padres are 58-42 this year and 30-24 as the underdog. San Diego has won two straight games as the favorite. San Diego is 31-48 against the run line at home this season, but they are 47-28 on the road. Their average run differential is +0.6 runs per game, and they are 78-76 against the run line overall. The Padres have been favored in 100 of their games, and they are 41-59 against the run line in those contests.San Diego has been a solid over team this season, with an over/under record of 80-71. Their games have averaged 8.9 runs per game this season, and their games have had an average over/under line of 8 runs. When the line has been set at exactly 8 runs, their over/under record is 12-15-1. The under has hit in their last five games.Left-hander Martín Pérez gets the start for the Padres today as he faces the White Sox at home. He has made 24 starts this season and has a record of 4-5 with an ERA of 4.36. Looking at his overall numbers, opponents are batting .278 this season. In his 24 appearances, Pérez has turned in eight quality starts and is averaging 7 strikeouts per nine innings. The last time he took the mound, he finished with a no-decision, going five innings and giving up one earned run on two hits. Before that, he had given up at least four earned runs in three straight starts.San Diego comes into today's game with the league's top batting average at .265 and are also one of the top home run hitting teams in the league. Overall, they are 8th in the league in scoring (4.7 runs per game) and have been even better on the road, averaging 5.1 runs per contest. The Padres also do a great job of putting the ball in play, as they have the fewest strikeouts in the league.

Manny Machado has been swinging the bat well of late, going 9/25 with three homers over his last six games. This has helped him move into the team lead in home runs (29) and RBIs (104). Machado also comes into the game with a four-game hitting streak. Luis Arraez and Jackson Merrill have also been key run producers for the Padres this season.

Chicago White Sox vs San Diego Padres Betting Pick & Prediction 9/21/24

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