San Francisco 49ers vs Seattle Seahawks Betting Pick & Prediction for 1/17

NFL Game preview

The San Francisco 49ers are set to meet the Seattle Seahawks in the 2025 Divisional Playoffs. The game takes place at Lumen Field in Seattle on Saturday, January 17, 2026, at 8:00 PM. The weather forecast predicts a cool day with clear skies, providing good conditions for this night game.

The 49ers come into this game with a postseason record of 1-0-0 and a regular season record of 12-5-0. They have performed well on the road with a 7-2-0 record. The Seahawks, on the other hand, finished their regular season with a 14-3-0 record. They have also been strong at home with a 6-2-0 record. This NFC West showdown will be broadcast on FOX.

San Francisco 49ers Team Preview

The San Francisco 49ers recently had a tough game against the Seattle Seahawks, losing 13-3. They struggled offensively, managing only 9 first downs and 120 passing yards. Brock Purdy had 127 yards and one interception, while Christian McCaffrey rushed for 23 yards and caught 6 passes.

Before the Seattle game, the 49ers had a high-scoring win against the Chicago Bears, 42-38. In that game, Brock Purdy threw for 303 yards and three touchdowns. Christian McCaffrey was key on the ground with 140 rushing yards and a touchdown.

Injuries are currently impacting the 49ers, with key players like George Kittle and Nick Bosa out for the season. Trent Williams and Fred Warner are questionable for their next game. Despite these challenges, the team will look to players like Jauan Jennings and Demarcus Robinson to step up.

49ers vs Seahawks Game Day Info

  • Sport: NFL
  • Teams: San Francisco 49ers vs. Seattle Seahawks
  • Venue: Lumen Field in Seattle, WA USA
  • Date: Saturday, January 17, 2026
  • Betting Odds: 49ers Moneyline +284, Seahawks Moneyline -357, 49ers Spread +7.5 (-115), Seahawks Spread -7.5 (-106), Total Over 44.5 (-113), Total Under 44.5 (-108)

Seattle Seahawks Team Preview

The Seattle Seahawks have been strong in recent games. They won against the San Francisco 49ers with a score of 13-3. The Seahawks had more first downs and rushing yards in that game.

Quarterback Sam Darnold is a key player for the Seahawks. He threw for over 4,000 yards this season. Jaxon Smith-Njigba is another standout player with 1,793 receiving yards.

The Seahawks’ defense has also been effective. They ranked 11th in opponent scores and 6th in sacks. Injuries might be a concern, with several players on the injured reserve list.

BTB Betting Pick

The 49ers are listed as +7.5 underdogs against the Seahawks. Despite the 49ers having a better passing offense, their defense ranks 26th in opponent scoring. The Seahawks have a solid defense, ranked 11th in opponent scoring. The projected score is Seahawks 27, 49ers 20. The Seahawks are favored to cover the spread.

The total for the game is set at 44.5 points. The 49ers have allowed more points this season, which could lead to a higher scoring game. With both teams having capable offenses, the projected total score is 47 points. The recommendation is to take the over.