Portland Trail Blazers vs San Antonio Spurs Betting Pick & Prediction for 4/21

The San Antonio Spurs and the Portland Trail Blazers are set to meet for Game 2 of the Western Conference First Round. The Spurs lead the series 1–0 after their victory in Game 1. This game will take place at Frost Bank Center on Tuesday, April 21, 2026, at 8:00 PM.
The Trail Blazers are looking to even the series with interim head coach Tiago Splitter at the helm. They finished the regular season with a 42-40 record and are ranked 8th in the Western Conference. The Spurs, coached by Mitch Johnson, ended their season with a strong 62-20 record, earning them the 2nd spot in the conference. The game will be broadcast on NBC.
Trail Blazers vs Spurs Game Day Info
- Sport: NBA
- Teams: Portland Trail Blazers vs. San Antonio Spurs
- Venue: Frost Bank Center
- Date: Tuesday, April 21, 2026
- Betting Odds: Spurs -11.5 (-111), Trail Blazers +11.5 (-110), Spurs MoneyLine -668, Trail Blazers MoneyLine +485
Portland Trail Blazers Team Preview
The Portland Trail Blazers have had a mixed postseason so far. They lost to the San Antonio Spurs by 13 points, scoring 98. Deni Avdija stood out with 30 points, 10 rebounds, and 5 assists in that game.
In a previous game against the Phoenix Suns, the Trail Blazers secured a win by 4 points. Avdija was key again, scoring 41 points and adding 7 rebounds and 12 assists. The team shot 45.5% from the field in that game.
During the regular season, Avdija led the team with an average of 24.2 points per game. Shaedon Sharpe and Jerami Grant also contributed significantly. However, Damian Lillard remains out due to an Achilles injury, impacting the team’s depth.
San Antonio Spurs Team Preview
The San Antonio Spurs recently won against the Portland Trail Blazers, 111-98. Victor Wembanyama led the team with 35 points and a field goal percentage of 61.9%. De’Aaron Fox and Stephon Castle also contributed with 17 points each.
In the regular season, the Spurs had a mixed performance. They lost to the Denver Nuggets 128-118. They had a strong win over the Dallas Mavericks with a score of 139-120, where Wembanyama scored 40 points.
The Spurs have strong team stats in the postseason. They rank 7th in points per game with 111 and 5th in rebounds per game with 45. Their defense is solid, allowing only 98 points per game, which is 3rd best.
BTB Betting Pick
The Trail Blazers are getting +11.5 points against the Spurs. The Spurs score 111 points per game, while the Trail Blazers score 106 points. With the Spurs’ strong defense allowing only 98 points per game, the Trail Blazers might struggle to cover the spread. Pick the Spurs to cover the -11.5 spread.
The total for the game is set at 220.5. The Spurs allow only 98 points per game, and the Trail Blazers score 106 points per game. This makes the total likely to be lower than expected. Choose the Under 220.5 for this game.