Philadelphia Eagles vs Buffalo Bills Betting Pick & Prediction for 12/28

NFL Game preview

The Philadelphia Eagles travel to Highmark Stadium to play the Buffalo Bills in Week 17 of the 2025 NFL season. The game takes place on Sunday, December 28, at 4:25 PM. Fans can watch the action on FOX as the Eagles aim to improve their 10-5 record against the 11-4 Bills.

Weather conditions in Orchard Park, NY, are expected to be very cold with light rain and breezy winds. The Eagles, led by head coach Nick Sirianni, have a road record of 5-3. Meanwhile, the Bills, guided by head coach Sean McDermott, have been strong at home with a 6-1 record. Both teams have the same division record of 3-2 this season.

Philadelphia Eagles Team Preview

The Philadelphia Eagles are coming off a strong win against the Washington Commanders, with a score of 29-18. Saquon Barkley led the team on the ground with 132 rushing yards and a touchdown. Jalen Hurts contributed with 185 passing yards and two touchdowns, showing a balanced offensive attack.

In their recent game against the Las Vegas Raiders, the Eagles dominated with a 31-0 victory. Jalen Hurts threw three touchdowns, and Dallas Goedert had two receiving touchdowns. The Eagles’ defense held the Raiders to just seven first downs and 29 passing yards.

The Eagles’ roster faces some challenges with injuries, including key players like Lane Johnson and Nakobe Dean listed as questionable. Despite these setbacks, the team has shown depth in their lineup. The Eagles continue to rely on strong performances from top players like A.J. Brown and Saquon Barkley to lead the offense.

Eagles vs Bills Game Day Info

  • Sport: NFL
  • Teams: Philadelphia Eagles vs. Buffalo Bills
  • Venue: Highmark Stadium in Orchard Park, NY USA
  • Date: Sunday, December 28, 2025
  • Betting Odds: Eagles Moneyline -101, Bills Moneyline -119, Eagles Spread +1.5 (-114), Bills Spread -1.5 (-107), Total Over 43.5 (-107), Total Under 43.5 (-114)

Buffalo Bills Team Preview

The Buffalo Bills have been strong in their recent games. They won their last four games, beating the Cleveland Browns, New England Patriots, Cincinnati Bengals, and Pittsburgh Steelers. Their only recent loss was against the Houston Texans with a score of 23-19.

In their recent game against the Browns, James Cook was key with 117 rushing yards and 2 touchdowns. Josh Allen added 12 completions and 130 yards. On defense, Greg Rousseau had 2.5 sacks, while Jordan Poyer grabbed an interception.

Josh Allen has played well this season with 3,406 passing yards and 25 touchdowns. James Cook leads the run game with 1,532 rushing yards and 12 touchdowns. The team faces some injuries, including Matt Prater and Jordan Poyer, who are both questionable for the next game.

BTB Betting Pick

The Eagles are listed at +1.5 (-114) against the Bills. The Eagles have a strong defense, ranked 2nd in opponent score, which can help them keep the game close. With their rushing offense ranked 2nd, they can control the clock. The projected score is Eagles 24, Bills 23, suggesting the Eagles can cover the spread.

The total for the game is set at 43.5. Both teams have top 10 offenses, but the Eagles’ defense is strong, ranked 1st in opponent offensive yards. This can limit scoring opportunities. The projected total score is 47, so taking the over is recommended.