Chicago Bears vs San Francisco 49ers Betting Pick & Prediction for 12/28

NFL Game preview

The Chicago Bears will travel to Levi’s Stadium to take on the San Francisco 49ers. This game is set for Sunday, December 28, 2025, at 8:20 PM. Fans can catch the action on NBC.

Both teams have an 11-4 record this season. The Bears have a 5-3 record on the road, while the 49ers hold a 4-2 record at home. The weather is expected to be clear, making for ideal playing conditions.

Chicago Bears Team Preview

The Chicago Bears have had a mixed bag of results in their recent games. They had a strong win against the Cleveland Browns, ending the game 31-3. Caleb Williams led the team with 242 passing yards and two touchdowns, while D’Andre Swift added 98 rushing yards and two touchdowns.

In the previous game against the Green Bay Packers, the Bears fell short with a 28-21 loss. Caleb Williams managed 186 passing yards and two touchdowns but also had an interception. D’Andre Swift and Kyle Monangai contributed on the ground with a combined 120 rushing yards.

Despite injuries, the Bears have shown strong performances from key players. D’Andre Swift has been a standout with 993 rushing yards this season. The team will look to continue their offensive efforts, despite several players being on the injury list, including C.J. Gardner-Johnson and Rome Odunze, who are both questionable for the upcoming game.

Bears vs 49ers Game Day Info

  • Sport: NFL
  • Teams: Chicago Bears vs. San Francisco 49ers
  • Venue: Levi’s Stadium in Santa Clara, CA
  • Date: Sunday, December 28, 2025
  • Betting Odds: Bears Moneyline +143, 49ers Moneyline -170

San Francisco 49ers Team Preview

The San Francisco 49ers have had a strong performance in recent games. They won against the Indianapolis Colts 48-27, showcasing their offensive strength. Brock Purdy led with 295 passing yards and five touchdowns, while Christian McCaffrey added 145 rushing yards.

The team continued its winning streak with a victory over the Tennessee Titans, scoring 37-24. The 49ers had 28 first downs and 292 passing yards. Jauan Jennings contributed with two touchdowns, and George Kittle added one more.

In their game against the Cleveland Browns, the 49ers won 26-8. They achieved 161 passing yards and 91 rushing yards. The defense stood strong, not allowing any passing touchdowns and forcing four fumbles.

BTB Betting Pick

The San Francisco 49ers are favored by 3 points against the Chicago Bears. The 49ers have a stronger offense, ranking 13th in scoring compared to the Bears at 26th. With their home-field advantage and better offensive stats, the 49ers are likely to cover the spread. The projected score is 49ers 27, Bears 20.

The total points line is set at 52.5. The Bears’ defense ranks 12th in opponent scoring, which may limit the 49ers’ scoring opportunities. The Bears’ offense struggles, ranking 26th in scoring, suggesting a lower-scoring game. The under is a safer pick with a projected total of 47 points.