Missouri Tigers vs Vanderbilt Commodores Betting Pick & Prediction for 10/25

Week 9 of the 2025 college football season brings an exciting game between the Missouri Tigers and the Vanderbilt Commodores. The game will be held at FirstBank Stadium in Nashville, TN, with kickoff set for 3:30 PM. Fans can catch the action on ESPN.
Missouri enters the game with a 6-1 record and ranks 15th in the AP poll. Vanderbilt also holds a 6-1 record and sits at 10th in the AP rankings. Both teams are part of the Southeastern Conference and have a conference record of 2-1. The game promises to be a competitive one, with Vanderbilt slightly favored by the oddsmakers.
Missouri Team Preview
The Missouri Tigers have had a strong season so far. They won against Auburn with a score of 23-17. In that game, they had 252 passing yards and 92 rushing yards.
In a close game, the Tigers lost to Alabama 27-24. They had 163 rushing yards and 167 passing yards. They managed to score but had two interceptions.
Missouri had a big win against Massachusetts, scoring 42-6. They gained 253 passing yards and 268 rushing yards. Their defense held Massachusetts to only nine first downs.
Missouri vs Vanderbilt Game Day Info
- Sport: NCAA Football
- Teams: Missouri Tigers vs. Vanderbilt Commodores
- Venue: FirstBank Stadium, Nashville, TN
- Date: Saturday, October 25, 2025
- Betting Odds: Missouri +120, Vanderbilt -144
Vanderbilt Team Preview
The Vanderbilt Commodores have shown strong performance in recent games. They secured a win against LSU Tigers with a score of 31-24. In this game, they achieved 20 first downs and dominated in rushing yards with 242.
In their game against the Alabama Crimson Tide, the Commodores faced a loss, 30-14. They managed 16 first downs and 198 passing yards. However, they struggled with two interceptions.
The Commodores’ offense has been effective this season, ranking 6th in points scored with 290. Their rushing game is ranked 19th with 1503 yards. Defense has also been solid, with 20 sacks placing them 9th in that category.
BTB Betting Pick
For the spread pick, consider taking Vanderbilt -2.5. Vanderbilt’s offense is ranked 6th in points scored, while Missouri’s defense is ranked 57th in points allowed. The projected score is Vanderbilt 28, Missouri 24, which suggests Vanderbilt can cover the spread.
For the over/under pick, the recommendation is to take the over 52.5. Vanderbilt and Missouri have strong offenses, with Vanderbilt scoring 290 points and Missouri 273 points this season. The projected total score is 52, which is very close to the line, but their offensive capabilities suggest the over is achievable.