Los Angeles Rams vs Denver Broncos Prediction & Odds — September 27, 2026
The Rams and Broncos both answered opening defeats with Week 2 victories. They meet in Denver on Sunday night with another question hanging over Los Angeles: how much of its receiving group will be available, with Puka Nacua listed doubtful.
Game details and odds
Sunday, September 27, 2026 at 8:20 p.m. EDT · Empower Field at Mile High
| Team | Spread (American price) | Moneyline |
|---|---|---|
| Los Angeles Rams | -2.5 (-110) | -135 |
| Denver Broncos | +2.5 (-110) | +114 |
Total: 43.5 — over -115, under -105.
DraftKings odds checked September 25, 2026, at 19:15 UTC. Odds subject to change.
Rams bring their rebound to Denver
Los Angeles lost 27–7 to San Francisco at Melbourne Cricket Ground, then beat the Giants 28–6 at SoFi Stadium. The opener counted as a Rams home game but was played at a neutral venue in Australia. Denver is their first opponent's home stadium of the regular season. The Giants result was a substantial response on both sides of the scoreboard; reproducing it in this setting is the next test.
Denver followed a 31–10 loss at Kansas City with a 20–13 home victory over Jacksonville. Holding the Jaguars to 13 points gave the Broncos a route to victory without needing a high-scoring afternoon. Another game of that kind would suit them here. Denver's opening defeat showed the difficulty of chasing a productive opponent, making it important to keep Los Angeles within reach early.
Los Angeles has options beyond the passing game
The Rams average 390 total yards per game to Denver's 292. Their rushing attack produces 142.5 yards per game against a Broncos defense allowing 157.5. Davante Adams has 221 receiving yards and two touchdowns, providing a major target alongside the ground game. Los Angeles has the stronger early yardage numbers, but converting that production into points remains the key against Denver.
Injury news
Nacua is doubtful with a hip issue. Rams Jordan Whittington and Colby Parkinson are questionable, as are Denver's Marvin Mims Jr. and Jonah Coleman. The receiving absences could alter Los Angeles' options; check final availability before kickoff. These statuses were checked Friday.
BTB Betting Pick
Winner pick: Los Angeles Rams. Spread: Pass. Total: Pass.
The Rams are the slight winner pick after their 28–6 response against the Giants. That performance gives Los Angeles a promising platform, although Denver's own home victory makes this a much tougher assignment than the previous scoreline might suggest.
The spread and total are passes. Denver has already won a lower-scoring game at this stadium, and the Rams have yet to show that their rebound can carry into an opponent's home ground. This looks closer than a straightforward endorsement of Los Angeles' last result.