Los Angeles Rams vs Arizona Cardinals Prediction & Odds – November 15, 2026

The Los Angeles Rams visit the Arizona Cardinals at State Farm Stadium with contrasting records and a clear road-home split. Los Angeles is 3-1 away; Arizona is still seeking its first home win.

Game details and odds

Sunday, November 15, 2026 at 4:05 pm EST · State Farm Stadium

Total: 39.5 — over -108, under -112.

DraftKings odds checked November 12, 2026 10:03 UTC. Odds subject to change.

Rams bring a balanced attack to Glendale

Los Angeles averages 390.6 yards and 23.8 points per game, with Matthew Stafford accounting for 2,374 passing yards and 16 touchdowns. Kyren Williams has added 593 rushing yards and six scores. The Rams also allow 20.1 points per game, giving them ways to compete beyond their passing production.

The Rams have won three straight, most recently holding Washington to 13 points in a 20-13 road victory. They also beat the Chargers 24-9 and scored 35 against the Raiders, showing they can win with either defense or a bigger offensive output. Their earlier 18-16 home loss to Arizona is a reminder that this matchup has already tested them: Los Angeles scored only 16 that day. The 34-37 loss to Buffalo before that featured a much different scoring pattern, underscoring how varied the Rams’ recent games have been.

Cardinals seek steadier scoring at home

Arizona averages 19.8 points per game while allowing 28.3, a difficult balance against a Rams team with multiple scoring options. Trey McBride leads the Cardinals with 73 catches, 598 receiving yards and five touchdowns. Arizona’s 0-3 home record adds pressure to turn promising stretches into a complete performance.

Arizona’s recent results swing sharply from one week to the next. The Cardinals managed only three points in a 17-3 loss at Seattle after scoring 33 in a road win over Dallas. They also beat the Rams 18-16 on the road, proof that a lower-scoring contest can suit them. Home games against Denver and Detroit went the other way: Arizona scored 16 and 21, respectively, while conceding 30 and 45. Keeping this meeting controlled matters more than chasing the kind of exchange they survived in Dallas.

Injury news

Los Angeles Rams: Puka Nacua – Out (Knee – MCL); Trent McDuffie – Questionable (Back); Kam Curl – Questionable (Toe); Myles Garrett – Questionable (Knee); Davis Allen – Questionable (Oblique).

Arizona Cardinals: Zachary Carter – Injured Reserve (Knee); Andrew Wingard – Questionable (Groin); Dante Stills – Questionable (Shoulder); Max Melton – Questionable (Knee); Bam Knight – Questionable (Concussion).

Availability checked November 12, 2026 10:03 UTC. Reported statuses may change; final lineups are not confirmed here.

BTB Betting Pick

Winner pick: Los Angeles Rams.

Los Angeles gets the nod on its stronger road record and more productive overall attack. Arizona already beat the Rams once, however, and another tight, lower-scoring game could narrow that edge.

Original winner pick recorded November 12, 2026 10:03 UTC. Subsequent updates retain that selection.