Arizona Cardinals vs San Francisco 49ers Betting Pick & Prediction 10/6/24

The 49ers are heavily favored in their week five matchup against the Cardinals, with the money line sitting at -358 for the 49ers and +280 for the Cardinals. The game, set for 4:05 ET on Sunday, October 6th at Levi’s Stadium in Santa Clara, CA, will be aired on FOX. The 49ers are -7.5 point favorites and the over/under line is 49.5 points.
ARIZONA CARDINALS VS SAN FRANCISCO 49ERS BETTING PICK
The Pick: San Francisco 49ers -7.5
This game will be played at Levi’s Stadium at 4:05 ET on Sunday, October 6th.
WHY BET THE SAN FRANCISCO 49ERS:
- We have the 49ers winning this one by a score of 32 to 23
- Not only do we have the 49ers winning straight-up, we have them covering the spread at -7.5
- Look for this game to go over the line of 49.5 points
Will The Cardinals Pull Off An Upset As Road Underdogs
The Cardinals were heavily favored at -3.5 but ended up losing 42-14 to the Washington Commanders at home, dropping their record to 1-3 for the season. Arizona’s defeat was even more lopsided than expected, as they lost by 28 points. The Commanders took control of the game in the 2nd quarter and outscored the Cardinals by 15 points in the 4th quarter.
Arizona did manage to tie the game 7-7 in the 1st quarter, with Kyler Murray connecting with Marvin Harrison Jr. for a touchdown. However, Washington responded, and the Cardinals trailed 17-7 at halftime. Although the Cardinals found the endzone in the 3rd quarter with a James Conner touchdown, the Commanders extended their lead, and Arizona couldn’t mount any comeback.
The Cardinals’ offense struggled in their 42-14 loss to the Washington Commanders, managing only 115 yards passing on 22 attempts. Kyler Murray threw for 142 yards and one touchdown, but he was sacked four times. Arizona’s offense finished with 17 first downs and 181 rushing yards on 32 attempts, with James Conner leading the way with 104 yards and a 20-yard run.
Marvin Harrison Jr. was the top receiver with 45 yards and one touchdown. The Cardinals’ running game averaged 5.7 yards per attempt, but their inability to protect Murray and generate consistent passing yards hindered their overall performance.
In their 42-14 loss to the Washington Commanders, the Cardinals’ defense struggled to stop the run, giving up 216 yards on the ground across 37 attempts. Despite allowing just 233 passing yards, they gave up 7.8 yards per attempt. The defense also struggled on third down, allowing the Commanders to convert 75% of their third down attempts.
Arizona’s defense didn’t record any sacks in the game and allowed Washington to complete 86.7% of their passes. Additionally, they had a tough time in the backfield, losing the tackles for loss battle.
Are The 49ers Going To Defend Home Field Advantage?
The 49ers improved to 2-2 on the season with a 30-13 win over the Patriots. Looking at the game, the 49ers were up 20-3 at halftime and never really were in danger of losing this one. They were the favorite by -10.5 and covered the spread with their 17-point win. The combined 43 points easily surpassed the O/U line of 42 points.
San Francisco got things going with a 22-yard field goal with 8 seconds left in the 1st quarter. From there, they added two more touchdowns in the 2nd quarter. The Patriots did get the first touchdown in the 3rd quarter, but the 49ers quickly answered with a touchdown of their own to keep a comfortable lead.
The 49ers’ offense put up 30 points in their 30-13 win over the Patriots, with 19 first downs and 283 yards passing. They also ran for 148 yards on 32 attempts. Brock Purdy threw for 288 yards, completing 15 of 27 passes (55%) and throwing one touchdown. Jordan Mason led the team in rushing with 123 yards, averaging 5.1 yards per attempt, and also scored one touchdown.
Jauan Jennings was the top receiver with 88 yards, 45 of which came on a single reception. The 49ers converted on 53.8% of their third down attempts, but Purdy was sacked once and threw one interception.
In their most recent game, the 49ers’ defense put together a dominant performance, coming up with six sacks and holding the Patriots to just 73 rushing yards on 24 attempts. They also allowed only 143 passing yards and a completion percentage of 59.4%. Despite giving up one passing touchdown, the 49ers came away with one interception and limited New England to a 31.2% conversion rate on third down.
Their strong defensive effort helped the 49ers to a 30-13 victory, as they also won the QB hit differential by +6 and had four more tackles for loss than the Patriots.