Los Angeles Rams vs San Francisco 49ers Betting Pick & Prediction for 11/9

The Los Angeles Rams are heading to Levi’s Stadium to take on the San Francisco 49ers in Week 10 of the 2025 NFL season. The game is set for Sunday, November 9, at 4:25 PM and will be broadcast on FOX. The weather is expected to be mild with broken clouds, making for a pleasant day for football.

Both teams are in the NFC West and have strong records this season. The Rams, led by head coach Sean McVay, hold a 6-2 record. The 49ers, under head coach Kyle Shanahan, have a 6-3 record. The 49ers have the advantage at home with a solid 2-1 record at Levi’s Stadium, while the Rams are also strong on the road with a 3-1 record.

Los Angeles Rams Team Preview

The Los Angeles Rams have been strong in recent games. They secured a 34-10 win against the New Orleans Saints. Matthew Stafford led the charge with 281 yards and four touchdowns. Kyren Williams also helped with 114 rushing yards and a touchdown.

In their game against the Jacksonville Jaguars, the Rams won 35-7. Stafford threw for 182 yards and five touchdowns. Davante Adams was a key player with 35 receiving yards and three touchdowns.

The Rams’ defense has played well this season. Against the Baltimore Ravens, they allowed only three points. Quentin Lake stood out with an interception and five assisted tackles.

Rams vs 49ers Game Day Info

• Sport: NFL
• Teams: Los Angeles Rams vs. San Francisco 49ers
• Venue: Levi’s Stadium in Santa Clara, CA
• Date: Sunday, November 9, 2025
• Betting Odds: Rams -193, 49ers +161

San Francisco 49ers Team Preview

The San Francisco 49ers have had a mixed performance this season. They recently won against the New York Giants with a score of 34-24. In that game, Christian McCaffrey led the team with 106 rushing yards and a touchdown.

Mac Jones has been a key player for the 49ers. He has thrown for 1,832 yards and 10 touchdowns this season. However, he has also thrown 5 interceptions, which the team will need to work on reducing.

The 49ers are dealing with several injuries. Key players like Fred Warner and Nick Bosa are out for the season. The team will need to rely on their depth and adjust their strategy moving forward.

BTB Betting Pick

The Rams are favored by 3.5 points against the 49ers. The Rams have a strong passing offense, ranked 10th, while the 49ers have a weaker defense, ranked 26th in opponent scores. With these factors, picking the Rams to cover the spread seems reasonable. The projected score is Rams 28, 49ers 24.

The total for the game is set at 49.5 points. The Rams’ defense is ranked 16th in opponent scores, and the 49ers’ offense ranks 13th in scoring. These stats suggest a high-scoring game. Therefore, the recommendation is to take the over. The projected total score is 52 points.