Detroit Pistons vs Chicago Bulls Betting Pick & Prediction for 10/22

The NBA regular season is set to start with the Detroit Pistons visiting the Chicago Bulls at the United Center. Both teams are looking to start the season strong. The game will be on Wednesday, October 22, 2025, at 8:00 PM and can be watched on CHSN.

Detroit, under head coach J.B. Bickerstaff, had a 2-2 record in the preseason. The Pistons are part of the Eastern Conference, Central Division. Chicago, led by head coach Billy Donovan, finished the preseason with a 3-2 record. They also belong to the Eastern Conference and Central Division.

Pistons vs Bulls Game Day Info

• Sport: NBA
• Teams: Detroit Pistons vs. Chicago Bulls
• Venue: United Center
• Date: Wednesday, October 22, 2025
• Betting Odds: Pistons Spread -4.0 (-112), Bulls Spread +4.0 (-108), Pistons MoneyLine -175, Bulls MoneyLine +148, Over/Under 233

Detroit Pistons Team Preview

The Detroit Pistons are coming off a strong win against the Washington Wizards, 119-98. Cade Cunningham was instrumental with 16 points and 12 assists. Jalen Duren also contributed 20 points and 6 rebounds in the victory.

Before the win, the Pistons faced a tough game against the Cleveland Cavaliers, losing 118-100. Daniss Jenkins and Tobias Harris each scored 19 points. Despite the loss, Ausar Thompson showed effort with 9 points, 5 rebounds, and 4 assists.

The Pistons had another close game against the Milwaukee Bucks, losing 117-111. Cade Cunningham led with 26 points, 6 rebounds, and 6 assists. The team will look to build on their recent performances as they prepare for their next game against the Chicago Bulls.

Chicago Bulls Team Preview

The Chicago Bulls recently secured a win against the Minnesota Timberwolves with a score of 126-120. Josh Giddey was key in this game, contributing 14 points and 9 assists. Dalen Terry also helped with 9 rebounds and 4 assists.

In their game against the Denver Nuggets, the Bulls lost 117-124. Josh Giddey stood out again, scoring 25 points and grabbing 9 rebounds. Matas Buzelis also added 20 points to the team’s total.

The Bulls faced a 121-127 loss against the Milwaukee Bucks. Ayo Dosunmu led the team with 22 points and 3 rebounds. Josh Giddey contributed with 8 rebounds and 7 assists in this game.

BTB Betting Pick

The Pistons are favored by 4 points against the Bulls. With both teams having no available stats, the Pistons’ status as favorites suggests they might cover the spread. The pick is for the Pistons to win against the spread at -4.0.

The over/under for the game is set at 233 points. Without data on scoring or defense, predicting a high or low score is challenging. However, given the line, the pick is to go under 233, considering the teams might not reach that total.