Detroit Red Wings vs Buffalo Sabres Betting Pick & Prediction for Wednesday on 10/22

This article was published on Oct 22, 2025. Today’s picks NHL picks

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The NHL Regular Season is underway, and the Detroit Red Wings visit the Buffalo Sabres at the KeyBank Center. The game is scheduled for Wednesday, October 22, 2025, at 7:30 PM. Fans can catch the action live on TNT.

Detroit Red Wings, coached by Todd McLellan, have started strong with a 5-1-0 record. They sit at the top of the Eastern Atlantic Division. The Buffalo Sabres, led by Lindy Ruff, have a 2-4-0 record and are looking to improve their standing. Both teams aim to gain momentum early in the season.

Red Wings vs Sabres Game Day Info

  • Sport: NHL
  • Teams: Detroit Red Wings vs. Buffalo Sabres
  • Venue: KeyBank Center
  • Date: Wednesday, October 22, 2025
  • Betting Odds: Buffalo Sabres MoneyLine -117, Detroit Red Wings MoneyLine -103

Detroit Red Wings Team Preview

The Detroit Red Wings have had a good start to their recent games. They have secured wins in their last five games. Their most recent victory was against the Edmonton Oilers with a score of 4-2.

In the 2026 season, the Red Wings have shown strength in scoring. They have a total of 20 goals, ranking them seventh. They also have 33 assists, placing them 11th.

Dylan Larkin has been a key player for the team. In six games, he has scored five goals and made six assists. Cam Talbot has also been reliable in goal with three wins out of four games.

Buffalo Sabres Team Preview

The Buffalo Sabres have shown mixed results in their recent games. They secured a solid win against the Florida Panthers with a 3-0 score. However, they faced challenges against the Montreal Canadiens, losing 4-2.

In the current season, the Sabres have scored 15 goals, ranking them 12th overall. Their assists total 28, which places them 16th. On the defensive side, they have managed 88 blocks, ranking 18th.

Zach Benson is one of the standout players for the Sabres. He has played in three games, recording six assists and six points. In goal, Alex Lyon has been active, with two wins and 183 saves across six games.

BTB Betting Pick

The Buffalo Sabres are favored to win against the Detroit Red Wings. The moneyline for Buffalo is -117, while Detroit is at -103. Considering Buffalo’s slightly better odds and their position as favorites, picking the Sabres to win is recommended. The projected score is Buffalo 3, Detroit 2, supporting this choice.

The over/under line for this game is set at 6.0. Given the projected score of Buffalo 3, Detroit 2, the total comes to 5 goals. This suggests taking the under at -107 is a reasonable pick, as both teams have shown moderate scoring and defense in their recent games.