Philadelphia 76ers vs Boston Celtics Betting Pick & Prediction for 10/22

The NBA regular season is kicking off with the Philadelphia 76ers taking on the Boston Celtics at TD Garden. Both teams are starting fresh with a 0-0 record. Fans can catch the game on NBCS on Wednesday, October 22, 2025, at 7:30 PM.

Nick Nurse leads the 76ers as they visit Boston. Philadelphia had a tough preseason with a 1-3 record. Joe Mazzulla’s Celtics had a better preseason, finishing 3-1. Both teams are part of the Eastern Conference’s Atlantic Division.

76ers vs Celtics Game Day Info

• Sport: NBA
• Teams: Philadelphia 76ers vs. Boston Celtics
• Venue: TD Garden
• Date: Wednesday, October 22, 2025
• Betting Odds: 76ers Spread -2.5 (-111), Celtics Spread +2.5 (-109), 76ers MoneyLine +114, Celtics MoneyLine -135, Over/Under 228.5

Philadelphia 76ers Team Preview

The Philadelphia 76ers are coming off a strong win against the Minnesota Timberwolves. Tyrese Maxey led the team with 27 points, 4 rebounds, and 7 assists. VJ Edgecombe also had a great game with 26 points and 6 rebounds.

In a previous game, the 76ers struggled against the Orlando Magic, losing by 30 points. Kennedy Chandler was the top performer for the 76ers with 16 points and 5 assists. The team had a tough time shooting, making only 38.8% of their shots.

Joel Embiid and Tyrese Maxey are key players for the 76ers. Embiid averages 23.8 points and 8.2 rebounds per game. Maxey, on the other hand, averages 26.3 points and 6.1 assists per game.

Boston Celtics Team Preview

The Boston Celtics recently played three preseason games. They won against the Toronto Raptors 110-108 at home. In this game, Derrick White scored 33 points and had 9 rebounds.

In another home game, the Celtics defeated the Cleveland Cavaliers 138-107. Anfernee Simons led the team with 21 points. The Celtics shot 52.4% from the field in that game.

The Celtics lost an away game to the Raptors by a score of 107-105. Chris Boucher scored 19 points and grabbed 9 rebounds. The team made 45.8% of their field goals in this matchup.

BTB Betting Pick

The spread for the game has the 76ers at -2.5 with odds of -111. The Celtics are +2.5 with odds of -109. Without specific stats available, the Celtics are favored. Considering the odds and the spread, picking the Celtics +2.5 is a reasonable choice for this game.

The over/under line for the game is set at 228.5. Both teams have no available stats to determine scoring trends. Without these details, it’s hard to predict a high or low-scoring game. Given the uncertainty, the under at 228.5 with odds of -112 seems like a safer pick.