Tennessee Titans vs San Francisco 49ers Betting Pick & Prediction for 12/14

NFL Game preview

The Tennessee Titans travel to Levi’s Stadium to take on the San Francisco 49ers in Week 15 of the 2025 NFL season. The game is set for Sunday, December 14, with a kickoff at 4:25 PM. Fans can catch the action on FOX as these two teams meet under clear skies in Santa Clara. The Titans come into the game with a 2-11 record, struggling this season under interim head coach Mike McCoy. They have found some success on the road, winning two out of six games. The 49ers, led by Kyle Shanahan, hold a 9-4 record and are strong contenders in the NFC West. They have been solid at home, with three wins in five games at Levi’s Stadium.

Tennessee Titans Team Preview

The Tennessee Titans have had a rough season. They have struggled offensively, ranking 26th in passing yards last season. Their recent games show a mix of highs and lows. They secured a close win against the Cleveland Browns, 31-29, but had losses to teams like the Jacksonville Jaguars, where they scored only 3 points.

On the field, Tony Pollard leads the Titans’ rushing attack. He has accumulated 743 rushing yards and 4 touchdowns this season. Cameron Ward, their quarterback, has thrown for 2468 yards with 9 touchdowns and 7 interceptions over 13 games.

The Titans face challenges with injuries to key players. Wide receiver Calvin Ridley is out for the season with a broken fibula. Other players like Blake Hance and Will Levis are also on the injured reserve list. The Titans will need to rely on their depth and players like Chimere Dike to step up in the coming games.

Titans vs 49ers Game Day Info

  • Sport: NFL
  • Teams: Tennessee Titans vs. San Francisco 49ers
  • Venue: Levi’s Stadium in Santa Clara, CA
  • Date: Sunday, December 14, 2025
  • Betting Odds: Titans +610, 49ers -911

San Francisco 49ers Team Preview

The San Francisco 49ers are having a strong season. They recently won against the Cleveland Browns, scoring 26-8. Brock Purdy led the team with 161 passing yards and a touchdown.

The team has also seen success at home. They defeated the Carolina Panthers 20-9. Christian McCaffrey was a key player, rushing for 89 yards and a touchdown.

Despite injuries, the 49ers have maintained their performance. They have secured wins in four of their last five games. The team aims to continue their winning streak in upcoming games.

BTB Betting Pick

The Titans are getting +12.5 points against the 49ers. The 49ers have a stronger offense, ranked 13th in scoring, compared to the Titans’ 25th. However, the Titans’ defense ranks 2nd in opponent offensive yards, which could help them cover the spread. The recommendation is to pick the Titans to cover +12.5.

The total for the game is set at 44.5 points. The 49ers have a better offense, but both teams have defenses ranked in the top 10 for interceptions. This could limit scoring opportunities. The projected score suggests a lower total, so the recommendation is to pick the under 44.5.