Tennessee Titans vs Indianapolis Colts Betting Pick & Prediction 12/22/24
This article was published on Dec 17, 2024. Today’s picks NFL picks

The Colts are favored at -218 on the money line as they host the Titans at 1:00 ET on Sunday, December 22nd at Lucas Oil Stadium. The Colts are -4.5 point favorites on the point spread. This week 16 AFC South matchup is being televised on CBS, and the over/under line is set at 42.5 points.
TENNESSEE TITANS VS INDIANAPOLIS COLTS BETTING PICK
The Pick: Indianapolis Colts -4.5
This game will be played at Lucas Oil Stadium at 1:00 ET on Sunday, December 22nd.
WHY BET THE INDIANAPOLIS COLTS:
- We have the Colts winning this one by a score of 23 to 16
- Not only do we have the Colts winning straight-up, we have them covering the spread at -4.5
- We see this game finishing below the line of 42.5 points
Will The Titans Pull Off An Upset As Road Underdogs
With a 3-11 record, the Titans are in 4th place in the AFC South and have a -8.9 scoring margin. They’ve lost three straight, including a 37-27 defeat to the Bengals in week 15. Tennessee was a 6-point underdog in that game, and the 64 combined points easily hit the over (O/U line: 46.0).
Heading into week 16, the Titans have a 0.0% chance of making the playoffs. They rank 28th in our NFL power rankings and are 2-12 against the spread. Their O/U record is 8-5-1, with their games averaging 45.2 points per game.
Heading into week 16, the Titans rank 30th in our offensive power rankings. They are 24th in the NFL in scoring, averaging 18.1 points per game, and 26th in total yards per game with 301. Tennessee ranks 19th in passing attempts and 26th in passing yards per game, averaging 190.6. On the ground, they are 18th in both rushing attempts and rushing yards per game, with 110.4. The Titans are 22nd in the NFL in third-down conversion rate (36.6%) but have been efficient in the red zone, ranking 8th with a 39.5% conversion rate.
Mason Rudolph took over at quarterback in week 15, throwing for 209 yards and 2 touchdowns on 21/26 passing, with 1 interception. Tony Pollard led the rushing attack with 45 yards on 17 carries, while Tyjae Spears had 6 receptions for 87 yards and a touchdown. The Titans scored 14 points in the first quarter and 13 in the fourth, converting all 4 of their red zone opportunities and 5 of 8 third downs.
In their most recent game, the Titans’ defense gave up 269 passing yards on 26 completions to the Bengals. They also allowed three passing touchdowns and a 70.3% completion percentage to Cincinnati. The Titans’ defense struggled on third downs, allowing the Bengals to convert 76.9% of their third down attempts. Despite forcing two interceptions, the Titans lost 37-27.
Tennessee’s defense managed just one sack in the game and allowed the Bengals to convert on several key third downs. They also struggled to defend the run, allowing 101 rushing yards on 26 attempts. Additionally, the Titans’ defense allowed the Bengals to hit on big plays, as they finished with a 7.3 yards per pass attempt.
Are The Colts Going To Defend Home Field Advantage?
Heading into week 16, the Colts sit 2nd in the AFC South with a 6-8 record, including a 5-5 mark in conference play. Our power rankings have them 23rd, and they have an 8.7% chance of making the playoffs. Indianapolis is 8-6 against the spread, but they have failed to cover in three straight games. Their O/U record is 7-7, with the over hitting in their last two games.
After beating the Patriots in week 13, the Colts couldn’t keep the momentum going, falling 31-13 to the Broncos in week 15. The loss dropped them to 3-5 on the road this season. They were 4.5-point underdogs in the game but couldn’t cover the spread, and the 44 combined points narrowly went over the 43.5-point line.
Heading into week 16, the Colts rank 28th in our offensive power rankings, sitting 20th in both points per game (20) and total yards per game (311.4). They’ve leaned on the run game, averaging 120.9 rushing yards per game (12th) on 27.1 attempts per game. On the passing side, they rank 27th in the NFL with 190.4 yards per game, while also ranking 24th in 3rd-down conversions with a 35.8% success rate.
In week 15, Anthony Richardson threw for 172 yards (17/38) with 2 interceptions against the Broncos, posting a passer rating of 36. Jonathan Taylor led the rushing attack with 107 yards on 22 carries, while Michael Pittman Jr. had 6 catches for 58 yards. After scoring 13 points in the first half, the Colts were shut out in the 2nd half.
In their 31-13 loss to the Broncos, the Colts’ defense struggled to generate pressure, finishing with just one sack and losing the QB hit differential by -9. Despite this, they did manage to force three interceptions and held the Broncos to 72 yards on 27 rushing attempts (2.7 yards per attempt). Indianapolis gave up only 121 passing yards but allowed three passing touchdowns.
The Colts’ defense limited the Broncos to just 60.6% completions and held them to a 35.3% third-down conversion rate. However, their offense’s inability to sustain drives put them on the field for 33:13 minutes in the game.
