Tennessee Titans vs Arizona Cardinals Betting Pick & Prediction for 10/5

NFL Game preview

The Tennessee Titans are set to play against the Arizona Cardinals in Week 5 of the 2025 NFL season. This game will take place at State Farm Stadium in Glendale, Arizona. The game is scheduled for Sunday, October 5, 2025, at 4:05 PM and will be broadcast on CBS.

The Titans are looking for their first win of the season as they come into this game with a 0-4 record. The Cardinals, on the other hand, have a balanced 2-2 record and will try to improve their standing. With the retractable roof at State Farm Stadium, weather conditions should not impact the game.

Tennessee Titans Team Preview

The Tennessee Titans have faced challenges in their recent games. They lost 26-0 to the Houston Texans, struggling with only 93 passing yards and 82 rushing yards. Their defense also found it hard to hold off the Texans, giving up 224 passing yards and 129 rushing yards.

In another game against the Indianapolis Colts, the Titans were defeated 41-20. Their offense managed 196 passing yards and 86 rushing yards, but the Colts outpaced them with 228 passing yards and 137 rushing yards. Cameron Ward threw for 219 yards with one touchdown and one interception.

The Titans have key players on the injury list, including Calvin Ridley and Kevin Zeitler. This could affect their performance in upcoming games. With a string of losses, the Titans aim to improve their strategies and get back on the winning track.

Titans vs Cardinals Game Day Info

  • Sport: NFL
  • Teams: Tennessee Titans vs. Arizona Cardinals
  • Venue: State Farm Stadium in Glendale, AZ
  • Date: Sunday, October 5, 2025
  • Betting Odds: Titans Moneyline +326, Cardinals Moneyline -420, Titans Spread +7.5 (-111), Cardinals Spread -7.5 (-109), Total Over/Under 42.0 (-110)

Arizona Cardinals Team Preview

The Arizona Cardinals have been through a challenging start to their season. They have lost two close games recently. The Cardinals fell to the Seattle Seahawks 23-20 and the San Francisco 49ers 16-15. However, they managed a win against the Carolina Panthers with a score of 27-22 earlier in the season.

Kyler Murray leads the team as the quarterback. In the recent games, he has shown consistency with his passing, recording over 700 passing yards so far. Marvin Harrison Jr. and Trey McBride have been key targets, contributing significantly to the team’s passing game.

The Cardinals’ defense has shown strength in some areas. Calais Campbell and Jalen Thompson have made solid contributions in recent games. Injuries have been a concern, with several players on the injured reserve, affecting both offense and defense. The team will need to rely on depth and adaptability as they head into the next game.

BTB Betting Pick

The Titans are underdogs with a spread of +7.5. Their offense ranks low, scoring only 311 points last season. The Cardinals scored 400 points, ranking 12th. The Titans’ defense allowed 460 points, ranking 27th. The Cardinals’ defense allowed 379 points, ranking 14th. The Cardinals should cover the spread with a projected score of Cardinals 28, Titans 17.

The total for the game is set at 42.0. The Titans’ offense struggled, ranking 25th in scoring. The Cardinals’ offense was better, but their defense ranks 21st in yards allowed. The Titans’ defense allowed the second-most yards. The projected total score of 45 suggests taking the over.