StaffDNA Cure Bowl: Old Dominion Monarchs vs South Florida Bulls Betting Pick & Prediction for 12/17

The 2025 StaffDNA Cure Bowl will feature the Old Dominion Monarchs taking on the South Florida Bulls. This game is set for Wednesday, December 17, 2025, at Camping World Stadium in Orlando, FL. Fans can catch the action live on ESPN at 5:00 PM.

Both teams come into this postseason game with identical 9-3 records. The Monarchs hail from the Sun Belt Conference, while the Bulls represent the American Conference. Each team held an undefeated home record this season, which adds an interesting element to this neutral field showdown.

Old Dominion Team Preview

The Old Dominion Monarchs have performed well in their recent games. They won against Georgia State 27-10, with strong rushing yards of 306. This helped them achieve 27 first downs, showing their ability to control the game.

In the game against Georgia Southern, Old Dominion had a big win with a 45-10 score. They gained 380 rushing yards and 175 passing yards. Their defense also held Georgia Southern to just 49 rushing yards.

Old Dominion has some key players contributing to their success. Colton Joseph leads as the quarterback with 2624 passing yards and 21 touchdowns. The team also relies on Trequan Jones, who has 736 rushing yards and five touchdowns this season.

StaffDNA Cure Bowl: Old Dominion vs South Florida Game Day Info

• Sport: NCAA Football
• Teams: Old Dominion Monarchs vs. South Florida Bulls
• Venue: Camping World Stadium in Orlando, FL
• Date: Wednesday, December 17, 2025
• Betting Odds: Old Dominion +181, South Florida -221

South Florida Team Preview

The South Florida Bulls have shown strong offensive performance this season. They scored 516 points, ranking 4th in the league. The Bulls have also accumulated 3315 passing yards, placing them at the 20th position.

Quarterback Byrum Brown leads the team with 3158 passing yards over 12 games. He has thrown 28 touchdowns, ranking him 1st in the team. On the ground, Nykahi Davenport has rushed for 603 yards, contributing significantly to the Bulls’ 2710 rushing yards this season.

Defense has been a point of focus, allowing 280 points, ranking 95th. They have recorded 29 sacks, standing at 13th place in the league. Injuries might be a concern with several players listed as questionable or out for the season.

BTB Betting Pick

The spread for the game is South Florida -5.5. Old Dominion has a strong rushing attack, ranking 7th in the nation. They also have a solid defense, allowing only 231 points this season. This suggests that Old Dominion can cover the spread.

The total for the game is set at 55.5. South Florida’s offense is strong, scoring 516 points this season. Old Dominion’s defense is also strong, so the total score may stay under 55.5.