St. Louis Cardinals vs Pittsburgh Pirates Betting Pick & Prediction for 4/29

MLB game preview

The St. Louis Cardinals will take on the Pittsburgh Pirates at PNC Park. The game is set for Wednesday, April 29, 2026, at 6:40 PM. Fans can catch the action on SN PT. The Cardinals come into the game with a record of 16-13, currently holding third place in the NL Central. They are on a two-game winning streak and have gone 5-5 in their last ten games.

On the other hand, the Pirates have a record of 16-14 and sit in fifth place in the division. They are looking to break a three-game losing streak and have a 4-6 record in their last ten games. The weather forecast for the game calls for moderate rain, so fans should be prepared. Andre Pallante will start for the Cardinals, while Bubba Chandler will take the mound for the Pirates.

St. Louis Cardinals Team Preview

The St. Louis Cardinals are coming off a strong win against the Pittsburgh Pirates. They scored 11 runs on 12 hits, with six being extra-base hits. Alec Burleson and Nolan Gorman were key hitters, contributing a combined six RBIs.

In their previous outing against the Pirates, the Cardinals secured a 4-2 win. Dustin May pitched six solid innings, allowing only two earned runs. JJ Wetherholt and Pedro Pagés each hit a home run, helping the team to victory.

Despite a recent loss to the Seattle Mariners, the Cardinals showed their power at the plate. They hit five home runs, with Nathan Church hitting two of them. Andre Pallante will be the starting pitcher for the next game, carrying a 4.26 ERA into the matchup.

Cardinals vs Pirates Game Day Info

  • Sport: MLB
  • Teams: St. Louis Cardinals vs. Pittsburgh Pirates
  • Venue: PNC Park in Pittsburgh, PA
  • Date: Wednesday, April 29, 2026
  • Betting Odds: Cardinals Moneyline +126, Pirates Moneyline -150, Cardinals Runline +1.5 (-167), Pirates Runline -1.5 (+140), Total Over 8.5 (-117), Total Under 8.5 (-104)

Pittsburgh Pirates Team Preview

The Pittsburgh Pirates have been struggling in their recent games. They lost their last three games against the St. Louis Cardinals and Milwaukee Brewers. In those games, their hitting was inconsistent, with a high of 13 hits against the Cardinals and only 2 hits against the Brewers.

Despite the losses, some players have performed well. Ryan O’Hearn hit a home run and had three RBIs in the game against the Cardinals. Konnor Griffin also contributed with a home run in the same game.

The Pirates’ pitching has shown some strengths this season. They have a team ERA of 3.61, which ranks 5th in the league. However, they have given up 23 home runs, ranking 2nd in the league for most allowed.

BTB Betting Pick

The Pirates are favored to win with a moneyline of -150. Their pitching staff has a strong ERA of 3.61, ranked 5th, and they hold opponents to a .221 batting average. Given their pitching strength, the Pirates are the pick to win straight up with a projected score of Pirates 5, Cardinals 3.

The total for the game is set at 8.5. The Cardinals’ pitching struggles with a 4.81 ERA, ranked 25th, while the Pirates have a lower slugging percentage ranked 20th. With these factors, the under 8.5 is the pick, as the combined score is projected to be 8.