St. Louis Cardinals vs Cincinnati Reds Betting Pick & Prediction for 5/22

MLB game preview

The St. Louis Cardinals will take on the Cincinnati Reds in an MLB regular-season game. The Cardinals have a record of 28-21 and are ranked third in the NL Central division. They are currently on a two-game losing streak and have split their last ten games evenly.

The Reds have a 26-24 record and are in fourth place in the NL Central. They are riding a two-game winning streak, also going 5-5 in their last ten games. The game will be held at Great American Ball Park in Cincinnati, with the first pitch scheduled for 6:40 PM.

St. Louis Cardinals Team Preview

The St. Louis Cardinals have had mixed results in their recent games. They lost their last two games against the Pittsburgh Pirates, with scores of 6-2 and 7-0. However, they secured a win by beating the Pirates 9-6 in a game where they hit four home runs.

In their recent performances, several players have stood out for the Cardinals. Alec Burleson has been consistent, with a batting average of .290 and 34 RBIs. Iván Herrera has also contributed with a .262 average and six home runs.

The Cardinals’ pitching has had ups and downs. Kyle Leahy, who is set to start against the Cincinnati Reds, has a record of 5-3 with a 3.94 ERA. The team will look to improve their pitching as they face the Reds next.

Cardinals vs Reds Game Day Info

  • Sport: MLB Regular Season
  • Teams: St. Louis Cardinals vs. Cincinnati Reds
  • Venue: Great American Ball Park in Cincinnati, OH
  • Date: Friday, May 22, 2026
  • Betting Odds: Cardinals Moneyline -107, Reds Moneyline -113, Total Over 9.5 (-109), Total Under 9.5 (-111)

Cincinnati Reds Team Preview

The Cincinnati Reds have been showing mixed results in recent games. On May 20th, they secured a 9-4 win against the Phillies. Sal Stewart and Nathaniel Lowe led the charge with multiple hits, and Andrew Abbott pitched 5 1/3 innings, allowing just one earned run.

Despite a strong start from Chase Burns on May 19th, the Reds only managed seven hits. However, they still managed to win 4-1 against the Phillies. Elly De La Cruz contributed with a triple, and Tyler Stephenson had a perfect day at the plate with a single hit.

The Reds’ offense ranks 9th in slugging percentage, thanks to their power hitting. Elly De La Cruz and Sal Stewart have been standout players, each contributing significantly to the home run tally. The team faces challenges with pitching, as Chris Paddack, the probable starter, holds a 7.07 ERA this season.

BTB Betting Pick

The game between the Cardinals and Reds has tight moneyline odds, with the Cardinals at -107 and the Reds at -113. The Reds have a slight edge in hitting, ranking higher in home runs and doubles. Given their stronger offensive stats, picking the Reds to win straight up is a solid choice.

The total for the game is set at 9.5 runs. Both teams have mid-tier pitching, with the Cardinals’ ERA at 4.24 and the Reds’ at 4.73. Considering the decent offensive rankings and average pitching, betting on the over 9.5 runs seems reasonable. The projected score is around 6-5 in favor of the Reds.