Seattle Mariners vs St. Louis Cardinals Betting Pick & Prediction for 4/25

MLB game preview

The Seattle Mariners and the St. Louis Cardinals are set to play in the MLB regular season. The game will take place at Busch Stadium in St. Louis, MO, on Saturday, April 25, 2026, at 2:15 PM. Fans can catch the action on SEAM as the Mariners aim to extend their winning streak to three games.

The Mariners, with a record of 12-15, are currently third in the AL West division. They have struggled on the road with a 2-8 record. The Cardinals hold a 14-11 record and are fourth in the NL Central. They look to bounce back after losing their last two games.

Seattle Mariners Team Preview

The Seattle Mariners are coming off a recent win against the St. Louis Cardinals. They managed a narrow 3-2 victory with only four hits. Josh Naylor contributed with a home run, and George Kirby pitched six solid innings.

In their last five games, the Mariners have shown mixed results. They have secured three wins and two losses. The team has managed to hit 26 home runs this season, ranking them 10th in the league.

Bryan Woo is expected to start on the mound for the Mariners. He has a 2.25 ERA with 26 strikeouts in the 2026 season. His performance will be crucial in keeping the Mariners in the game against the Cardinals.

Mariners vs Cardinals Game Day Info

  • Sport: MLB
  • Teams: Seattle Mariners vs. St. Louis Cardinals
  • Venue: Busch Stadium in St. Louis, MO
  • Date: Saturday, April 25, 2026
  • Betting Odds: Mariners Moneyline -149, Cardinals Moneyline +125, Mariners Runline -1.5 (+116), Cardinals Runline +1.5 (-140), Total Over 7.5 (-121), Total Under 7.5 (-104)

St. Louis Cardinals Team Preview

The St. Louis Cardinals are looking to bounce back after a close game against the Seattle Mariners. In that game, they managed to record 8 hits but fell short with a 3-2 score. Andre Pallante delivered a strong performance with 8 strikeouts over 5 1/3 innings.

Offensively, the Cardinals have some key contributors. Masyn Winn has been consistent, hitting .270 with 11 RBIs. Alec Burleson is also a standout, boasting a .269 average with 17 RBIs, making him a crucial part of the lineup.

On the mound, Matthew Liberatore is set to start the next game. So far this season, he holds a 3.67 ERA with 16 strikeouts. The Cardinals will rely on him to keep the Mariners’ bats in check and aim for a win at home.

BTB Betting Pick

The Mariners are favored to win with a moneyline of -149. Their pitching staff ranks 5th in ERA and 2nd in quality starts, which gives them an edge over the Cardinals. The Cardinals’ pitching ranks 26th in ERA, making it tough for them to contain the Mariners’ lineup. I recommend picking the Mariners to win.

The total for the game is set at 7.5. The Mariners have a strong pitching lineup, but their batting average is only .223, ranked 21st. The Cardinals have a higher batting average at .230, but their pitching struggles with an ERA of 4.70. With both teams having challenges in either hitting or pitching, I recommend taking the under 7.5.