San Francisco 49ers vs Seattle Seahawks Betting Pick & Prediction 10/10/24
This article was published on Oct 8, 2024. Today’s picks NFL picks

At 8:15 ET, the Seahawks and 49ers will face off in a week six NFC West matchup. The game, played at Lumen Field in Seattle, is being televised by AMZN. The 49ers are favored on the road, with money line odds of -180 and a -3.5 point spread. The over/under line is at 47.5 points.
SAN FRANCISCO 49ERS VS SEATTLE SEAHAWKS BETTING PICK
The Pick: San Francisco 49ers -3.5
This game will be played at Lumen Field at 8:15 ET on Thursday, October 10th.
WHY BET THE SAN FRANCISCO 49ERS:
- We have the 49ers winning this one by a score of 27 to 21
- Not only do we have the 49ers winning straight-up, we have them covering the spread at -3.5
- Look for this game to go over the line of 47.5 points
Will The 49ers Win As Road Favorites?
After snapping a two-game losing streak with a week 4 win over the Patriots, the 49ers couldn’t keep the momentum going, losing 24-23 to the Cardinals at home in week 5. San Francisco was a 7-point favorite in the game, but the loss dropped their record to 2-3. They are now 0-2 in division games and 0-2 on the road, but they are 2-1 at home this season.
Despite their losing record, the 49ers rank 4th in our NFL power rankings and have a 50.7% chance of making the playoffs and a 41.8% chance of winning the NFC West. Against the spread, they are 2-3, having been favored in all of their games so far. Their O/U record is 3-2, with their games averaging 46.4 points per game.
Heading into week 6, the 49ers are 9th in the NFL in scoring, averaging 25.2 points per game, and they rank 2nd in the league with 407.4 passing yards per game. Brock Purdy threw for 244 yards in week 5 against the Cardinals, completing 19 of 35 passes with one touchdown and two interceptions. Before that, he had a 288-yard game in week 4 and a 292-yard, 3-touchdown performance in week 3 against the Rams.
Jordan Mason has been leading the 49ers’ rushing attack, posting 89 yards on 14 carries in week 5. In week 4, he had 123 yards on 24 carries, and in week 3, he ran for 77 yards. Brandon Aiyuk led the team in receiving in week 5, with 8 catches for 147 yards.
In their 24-23 loss to the Cardinals, the 49ers’ defense allowed 358 total yards. They struggled against the run, giving up 169 yards on just 26 attempts, with Arizona averaging 6.5 yards per attempt on the ground. Despite this, they did well against the pass, allowing only 189 yards through the air and holding the Cardinals to a 63.3% completion rate.
On third downs, the 49ers allowed the Cardinals to convert 30% of their chances. Although they only managed one sack, they did come up with one interception in the game.
Are The Seahawks Going Win In At Upset At Lumen Field
Seattle heads into week 6 looking to snap a two-game losing streak, which includes a 29-20 home loss to the Giants in week 5. The Seahawks were favored by 7 points but couldn’t get the win, dropping their record to 3-2. Despite the loss, they remain 1st in the NFC West, but our power rankings have them 23rd heading into week 6. We give Seattle a 28.1% chance of making the playoffs and a 21.6% chance of winning the division.
Seattle has an average scoring margin of +1.6 points per game and is 1-3-1 against the spread. They have an O/U record of 4-1, with the over hitting in two straight games. Their matchups have averaged 47.2 points per game, with an average O/U line of 42.4.
Seattle’s offense is currently 20th in our power rankings, but they lead the NFL in passing attempts per game (39.8) and are 3rd in passing yards, averaging 270.8 per game. Geno Smith threw for 284 yards (28/40) and a touchdown in week 5, after his 395-yard performance in week 4. DK Metcalf, who had 104 yards in weeks 3 and 4, is probable for week 6 against the 49ers.
On the ground, the Seahawks rank 28th in rushing attempts and 22nd in rushing yards, with 105.4 per game. Geno Smith led the team in week 5 with 72 rushing yards, while Kenneth Walker III had 80 yards and 3 touchdowns in week 4. Seattle ranks 16th in the NFL in 3rd-down conversions, with a 37.3% success rate.
In their most recent game, the Seahawks gave up 175 rushing yards on 34 attempts to the Giants. Overall, the Seattle defense allowed 420 yards in a 29-20 loss, with New York converting on 43.8% of their third down attempts. The Giants also had success through the air, throwing for 245 yards and completing 67.6% of their passes against Seattle. The Seahawks did manage to sack the quarterback three times.
The Giants’ ground game averaged 5.1 yards per attempt, and the Seahawks lost the battle in the tackles for loss department, finishing with a -4 differential. Despite their struggles defending the run, the Seattle defense will look to bounce back and tighten up in their upcoming games.
