San Francisco 49ers vs Los Angeles Rams Betting Pick & Prediction 9/22/24
This article was published on Sep 17, 2024. Today’s picks NFL picks

On the money line, the 49ers are -349 favorites as they take on the Rams at 4:25 ET on Sunday, September 22nd. The Rams are the underdogs at +276, with a point spread of +7 and an over/under line set at 43.5 points. This week three NFC West matchup is being televised on FOX, and is being played at SoFi Stadium in Inglewood, CA.
SAN FRANCISCO 49ERS VS LOS ANGELES RAMS BETTING PICK
The Pick: Los Angeles Rams +7
This game will be played at SoFi Stadium at 4:25 ET on Sunday, September 22nd.
WHY BET THE LOS ANGELES RAMS:
- We have the Rams winning this one by a score of 19 to 17
- Not only do we have the Rams winning straight-up, we have them covering the spread at +7
- We see this game finishing below the line of 43.5 points
Will The 49ers Win As Road Favorites?
Despite a 4-point favorite, the 49ers lost to the Vikings 23-17 on the road, resulting in a 1-1 record for the season. San Francisco fell behind early, with Minnesota taking a 3-0 lead in the 1st quarter. The 49ers managed to score in the 2nd quarter with a touchdown from Brock Purdy to Jauan Jennings but still trailed 13-7 at halftime. The Vikings extended their lead in the 3rd quarter, making it 20-7 heading into the 4th.
San Francisco made a push in the 4th quarter, with Purdy finding George Kittle for a touchdown and Jordan Mason adding a rushing touchdown. However, the Vikings also scored in the 4th, preventing any chance of a comeback. The combined 40 points were below the over/under line of 46.5 points.
Despite a strong performance from quarterback Brock Purdy, who threw for 319 yards and completed 77% of his passes, the 49ers fell to the Vikings 23-17. San Francisco’s offense recorded 24 first downs and 297 yards passing, with Purdy throwing one touchdown and leading the team in passing. The running game, led by Jordan Mason with 100 yards on 20 carries, added 102 yards on the ground.
The 49ers struggled on third down, converting only 20% of their chances, and their offense line allowed six sacks. Deebo Samuel Sr. was the top receiver with 110 yards on eight catches.
In the 49ers’ 23-17 loss to the Vikings, the defense allowed 403 total yards and 146 rushing yards on just 24 attempts. Despite forcing one interception and recording four sacks, the 49ers struggled to stop the Vikings’ running game, giving up 6.1 yards per attempt on the ground. Additionally, the defense allowed Minnesota to convert on 58.3% of their third down attempts.
In the passing game, the 49ers gave up 257 yards through the air, with Minnesota averaging 9.9 yards per attempt. Offensively, the 49ers lost the tackles for loss battle, with the Vikings being more disruptive in the backfield.
Are The Rams Going Win In At Upset At SoFi Stadium
After falling behind 14-0 in the first quarter, the Rams lost 41-10 to the Cardinals, dropping them to 0-2 for the season. The over/under line was set at 47.5 points, and the Cardinals surpassed that on their own. Los Angeles managed to score a field goal in the 2nd quarter but still trailed 24-3 at halftime.
Even though they found the endzone in the 3rd quarter with a Kyren Williams touchdown, the Rams were still behind 34-10 heading into the 4th. The Cardinals added one more touchdown in the 4th quarter to complete the blowout. Kyler Murray and Marvin Harrison Jr. connected for two touchdowns early, putting the Rams in a big hole right from the start.
The Rams’ offense struggled in their 41-10 loss to the Cardinals, managing just one touchdown and 14 first downs. They were held to 192 yards passing, with Matthew Stafford going 19/27 for 216 yards. Los Angeles couldn’t get anything going on the ground, finishing with only 53 rushing yards and 20 attempts.
Stafford was sacked five times and didn’t throw any touchdowns. Demarcus Robinson led the team with 50 receiving yards, while Blake Corum was the top rusher with 28 yards.
In their 41-10 loss to the Cardinals, the Rams’ defense struggled to stop the run, giving up 231 yards on 40 attempts. They also allowed Arizona to score three passing touchdowns, as they averaged 12.3 yards per attempt through the air. Overall, the Rams allowed 489 yards and 81% of Arizona’s passes to be completed.
On third downs, the Rams allowed the Cardinals to convert 63.6% of their chances. Additionally, the Rams’ defense only managed one sack and had a tackles for loss differential of -6.
