San Diego Padres vs Colorado Rockies Betting Pick & Prediction for 4/22

MLB game preview

The San Diego Padres are set to visit the Colorado Rockies at Coors Field for a regular season game. The Padres have a strong record of 16-7 and are second in the NL West division. They come into this game on a three-game winning streak and have won nine of their last ten games.

Meanwhile, the Rockies have a record of 9-15 and are in fifth place in the same division. They have lost their last two games and have struggled recently, winning only three of their last ten games. The game will be played at 8:40 PM on a warm night with a breezy crosswind and a few clouds in the sky.

San Diego Padres Team Preview

The San Diego Padres have shown strong performances in recent games. They managed three wins in their last four outings. The team has relied on solid pitching to secure victories, with standout performances from Randy Vásquez and Michael King.

In hitting, Xander Bogaerts leads with a .265 batting average and 14 RBIs. Manny Machado and Jake Cronenworth have contributed with home runs. Despite some struggles at the plate, the team ranks 4th in doubles this season.

Walker Buehler is set to start for the Padres against the Rockies. He has a 4.58 ERA with 18 strikeouts in the 2026 season. The Padres will look for another strong outing from him to continue their winning momentum.

Padres vs Rockies Game Day Info

  • Sport: MLB
  • Teams: San Diego Padres vs. Colorado Rockies
  • Venue: Coors Field in Denver, CO
  • Date: Wednesday, April 22, 2026
  • Betting Odds: Padres Moneyline -162, Rockies Moneyline +135, Padres Runline -1.5 (-109), Rockies Runline +1.5 (-112), Total Over 11.5 (-117), Total Under 11.5 (-104)

Colorado Rockies Team Preview

The Colorado Rockies have had a mixed set of results in their recent games. They lost their latest game against the San Diego Padres by one run, with a score of 1-0. The team’s offense struggled, managing only three hits and no extra-base hits.

In their game against the Los Angeles Dodgers on April 20th, the Rockies faced a tough loss with a score of 12-3. The team collected 11 hits and four extra-base hits, including one home run. Despite the loss, Jordan Beck had a standout performance with three hits and one RBI.

The Rockies secured a victory on April 19th against the Dodgers with a score of 9-6. They achieved 15 hits and six extra-base hits, including two home runs. Mickey Moniak contributed significantly with two hits, including a home run, and three RBIs.

BTB Betting Pick

The Padres are favored on the moneyline at -162. They have a strong pitching staff with a 3.22 ERA, which ranks 2nd in the league. The Rockies have a higher ERA at 4.26, which ranks 20th. Based on these stats, the Padres are the pick to win.

The total for the game is set at 11.5 runs. The Padres have given up the fewest home runs, with only 13 allowed, while the Rockies have allowed 32. Considering the Padres’ strong pitching, the under 11.5 at -104 is the recommendation.