Philadelphia Phillies vs San Diego Padres Betting Pick & Prediction for 5/25

MLB game preview

The Philadelphia Phillies are set to play the San Diego Padres at PETCO Park. The Phillies have a record of 26-27 and rank third in the NL East. They recently lost their last game but have a decent 6-4 record in their last 10 games.

The Padres hold a 31-21 record and sit second in the NL West. Like the Phillies, they also lost their last game and have a 6-4 record over the last 10 games. The game is scheduled for Monday, May 25, 2026, at 6:40 PM and will be aired on NBC.

Philadelphia Phillies Team Preview

The Philadelphia Phillies are coming off a series against the Cleveland Guardians. They managed to win one of the three games, showing some strong pitching performances. Zack Wheeler shined in their win, throwing six scoreless innings with six strikeouts.

At the plate, Kyle Schwarber is a key player for the Phillies. He leads the team with 20 home runs and 36 RBIs. Bryce Harper is also contributing with a batting average of .274 and 12 home runs.

The Phillies’ pitching staff has a 4.14 ERA this season. Jesús Luzardo is expected to start the next game, holding a 3-4 record and a 4.85 ERA. The team will look to improve their batting average, currently ranked 15th in the league at .229.

Phillies vs Padres Game Day Info

  • Sport: MLB
  • Teams: Philadelphia Phillies vs. San Diego Padres
  • Venue: PETCO Park in San Diego, CA
  • Date: Monday, May 25, 2026
  • Betting Odds: Phillies Moneyline -131, Padres Moneyline +110

San Diego Padres Team Preview

The San Diego Padres are looking to bounce back after a recent loss to the Athletics. They managed to get nine hits, with one home run by Ty France. Fernando Tatis Jr. also contributed with three hits, but it was not enough to secure a win.

In their previous win against the Athletics, the Padres showed strong pitching. Lucas Giolito held the Athletics scoreless over five innings. Despite only two hits, they managed to secure a 2-0 win with smart base running and patience at the plate.

Overall, the Padres have been struggling at the plate this season with a .220 batting average, which ranks them 20th in the league. Their pitching has been more solid, with a 3.86 ERA ranking 13th. Randy Vásquez will start the next game, bringing a strong 2.96 ERA into the matchup against the Phillies.

BTB Betting Pick

The Phillies are favored on the moneyline at -131. They have a better batting average and more home runs compared to the Padres. The Phillies’ pitching has a higher strikeout rate, which gives them an edge. The projected score is Phillies 4, Padres 3. So, the pick is the Phillies to win straight up.

The total for the game is set at 7.5. Both teams have shown average pitching stats, with the Phillies having a slightly higher ERA. The projected score of 7 suggests a close game. Therefore, the pick is on the Under 7.5.