Philadelphia Phillies vs Chicago Cubs Betting Pick & Prediction for 4/22

MLB game preview

The Philadelphia Phillies will take on the Chicago Cubs at Wrigley Field. The Phillies have had a tough season with an 8-15 record and are on a seven-game losing streak. They are ranked fourth in the NL East and have struggled in recent games, going 2-8 in their last ten.

The Cubs, on the other hand, are playing strong baseball. They have a 14-9 record and are second in the NL Central. The team has won their last seven games and have an 8-2 record in their last ten. The game is set for April 22, 2026, at 7:40 PM, and the weather is expected to be mild with a light breeze.

Philadelphia Phillies Team Preview

The Philadelphia Phillies have faced challenges in their recent games. They have lost five consecutive games, with their latest defeat being a 7-4 loss to the Chicago Cubs. Despite the losses, Kyle Schwarber and Bryce Harper have hit home runs, showing some spark in the lineup.

In the 2026 regular season, the Phillies are hitting with a batting average of .218, ranking them 22nd. Their on-base percentage stands at .298, which is 24th in the league. The team has managed to hit 24 home runs, placing them 8th in that category.

The Phillies’ pitching has struggled with a team ERA of 4.99, ranking them 28th. Opponents have a batting average of .276 against them, which is 26th in the league. Kyle Backhus will be the starting pitcher in the next game, carrying a 5.40 ERA with nine strikeouts this season.

Phillies vs Cubs Game Day Info

  • Sport: MLB
  • Teams: Philadelphia Phillies vs. Chicago Cubs
  • Venue: Wrigley Field, Chicago, IL
  • Date: Wednesday, April 22, 2026
  • Betting Odds: Phillies Moneyline +143, Cubs Moneyline -172

Chicago Cubs Team Preview

The Chicago Cubs have shown strong performance in their recent games. They won their last five games, including a 7-4 win against the Philadelphia Phillies on April 21st. In that game, Shota Imanaga pitched 7 innings, allowing just 1 earned run.

Offensively, the Cubs have a team batting average of .255, ranking 4th in the league. Nico Hoerner has been a key player, with a batting average of .326 and 22 RBIs. Dansby Swanson and Ian Happ have also contributed, with Swanson hitting 5 home runs this season.

Matthew Boyd is set to start the next game for the Cubs. He currently has a record of 1-1 with a 6.75 ERA. The Cubs will look to continue their winning streak against the Phillies.

BTB Betting Pick

The Cubs are favored with a moneyline of -172 against the Phillies, who have a moneyline of +143. The Cubs have a better batting average and on-base percentage, which gives them an edge in hitting. Their pitching also ranks higher with a 3.45 ERA compared to the Phillies’ 4.99 ERA. We recommend picking the Cubs to win this game.

The total for the game is set at 8.5 runs, with the over at -106 and the under at -115. The Cubs have a strong pitching staff, ranking 7th in ERA and 5th in batting average against. The Phillies have struggled in both pitching and hitting. Given these factors, the projected score is Cubs 5, Phillies 3, so taking the under 8.5 runs is recommended.