Ohio State Buckeyes vs Indiana Hoosiers Betting Pick & Prediction for 12/6

College Football Preview

The Big Ten Championship is set to take place in Week 15 of the 2025 season. The Ohio State Buckeyes will go against the Indiana Hoosiers. This game will be held at Lucas Oil Stadium in Indianapolis, Indiana, and will be televised on FOX.

Both teams enter the game with perfect 12-0 records. Ohio State holds the number one spot in both the AP and Coaches Polls. Indiana ranks second in both polls. The game is scheduled for Saturday, December 6, 2025, at 8:00 PM.

Ohio State Team Preview

Ohio State Buckeyes have had a strong season, with recent games showing their strength. In the game against Michigan, they won 27-9. Their defense held Michigan to only 9 first downs, while Ohio State had 22.

Julian Sayin has been a key player for the Buckeyes this season. He has passed for 3,065 yards and 30 touchdowns in 12 games. His performance ranks him first in the league for both categories.

Ohio State’s offense is ranked 13th in points for the season, with 444 points. Their defense has also been solid, allowing only 93 points. However, they have several players listed as questionable due to injuries, which could impact their next game.

Ohio State vs Indiana Game Day Info

  • Sport: NCAA Football
  • Teams: Ohio State Buckeyes vs. Indiana Hoosiers
  • Venue: Lucas Oil Stadium, Indianapolis, IN
  • Date: Saturday, December 6, 2025
  • Betting Odds: Ohio State -202, Indiana +168, Spread: Ohio State -4.5 (-111), Indiana +4.5 (-109), Total Over/Under: 48.5

Indiana Team Preview

The Indiana Hoosiers are on a strong winning streak. They recently beat Purdue 56-3, showing their strength on the road. The team had a solid rushing game with 355 yards against Purdue.

Indiana’s offense is one of the top in the nation. They rank 2nd in points scored with 532 points this season. Their rushing attack is ranked 9th with 2,830 yards.

Quarterback Fernando Mendoza leads the Hoosiers with impressive stats. He has thrown for 2,758 yards and 32 touchdowns. Running back Roman Hemby has also contributed with 866 rushing yards.

BTB Betting Pick

For the spread pick, Ohio State is favored by 4.5 points. Considering Ohio State’s strong defensive performance with only 93 points allowed this season, they have a good chance to cover the spread. The projected score is Ohio State 28, Indiana 21, suggesting Ohio State covers the -4.5 spread.

Looking at the over/under, the total is set at 48.5 points. With both teams showing strong offensive stats this season, especially Indiana with 532 points for, the game could exceed the total. The projected combined score of 49 points supports taking the over 48.5 points.