New York Yankees vs Boston Red Sox Betting Pick & Prediction for 4/22

MLB game preview

The New York Yankees travel to Fenway Park to play the Boston Red Sox. The game is set for Wednesday, April 22, 2026, at 6:45 PM. Fans can watch it on MLBN.

The Yankees come in with a 14-9 record and are first in their division. They have won their last four games. The Red Sox have a 9-14 record and are fifth in the division. They lost their last game and are 5-5 in their last ten games.

New York Yankees Team Preview

The New York Yankees have shown strong performance in their recent games. They secured a 4-0 win against the Boston Red Sox on April 21st. Luis Gil pitched 6 1/3 innings, allowing only 2 hits with no earned runs.

The Yankees’ hitting lineup has been effective, with Aaron Judge hitting 9 home runs this season. Ben Rice is leading the team with a .319 batting average and 8 home runs. Giancarlo Stanton also contributed with 3 home runs and a .253 batting average.

Max Fried is the probable starting pitcher for the Yankees in the next game. He has a 2-1 record with a 2.97 ERA and 23 strikeouts. The Yankees’ pitching staff has maintained a 3.25 ERA, ranking 3rd in the league.

Yankees vs Red Sox Game Day Info

  • Sport: MLB
  • Teams: New York Yankees vs. Boston Red Sox
  • Venue: Fenway Park in Boston, MA
  • Date: Wednesday, April 22, 2026
  • Betting Odds: Yankees Moneyline -142, Red Sox Moneyline +118, Yankees Runline -1.5 (+121), Red Sox Runline +1.5 (-145), Total Over 8.0 (-104), Total Under 8.0 (-117)

Boston Red Sox Team Preview

The Boston Red Sox have had mixed results in their recent games. They faced the New York Yankees on April 21st and lost 4-0. Their hitters struggled, managing only four hits and failing to score any runs.

In their game against the Detroit Tigers on April 20th, the Red Sox won 8-6. They collected 12 hits, with Carlos Narváez contributing with two hits and one RBI. The Red Sox starting pitcher, Sonny Gray, pitched 2 2/3 innings, giving up one earned run.

Ranger Suárez will be the starting pitcher for the Red Sox in their next game against the Yankees. Suárez has a record of 1-1 with a 3.22 ERA this season. He will aim to build on his strong eight-inning performance against the Tigers on April 17th, where he allowed no earned runs.

BTB Betting Pick

The Yankees are favored with a moneyline of -142, while the Red Sox are at +118. The Yankees have a strong slugging percentage, ranked 4th, and a solid pitching ERA of 3.25, which is 3rd best. These stats suggest the Yankees are likely to win, so the recommendation is to pick the Yankees to win straight up.

The total for the game is set at 8.0, with the over at -104 and the under at -117. The Yankees have been hitting well, ranking 3rd in home runs. The Red Sox pitching has a higher ERA at 4.38, which is 21st. With these factors, the projected score leans towards a combined total over 8 runs, so the recommendation is to pick the over.