Milwaukee Bucks vs Indiana Pacers Betting Pick & Prediction 4/22/25

At 7:00 ET, the Pacers (-186) will host the Bucks (+157) in a Central Division matchup. Indiana is currently favored by 4.5 points, and the over/under line is set at 228.5.
This game will take place at Gainbridge Fieldhouse in Indianapolis. The Pacers are 50-32 and have won two straight games, while the Bucks are 48-34 and sit fifth in the Eastern Conference.
MILWAUKEE BUCKS VS INDIANA PACERS BETTING PICK
The Pick: Milwaukee Bucks +4.5
This game will be played at Gainbridge Fieldhouse at 7:00 ET on Tuesday, April 22nd.
WHY BET THE MILWAUKEE BUCKS:
- We have this one finishing with a projected score of 147-131 in favor of the Bucks.
- Our projections have Giannis Antetokounmpo finishing with 30 points, 12 rebounds and 6 assists.
- From the field, we have the Bucks finishing with a field goal percentage of 47.8% and knocking down 17 threes.
Is a Road Win Possible for Milwaukee?
The Bucks fell to 48-34 on the season after a 117-98 loss to the Pacers on Saturday. Milwaukee entered the game as +6 point underdogs and failed to cover the spread. The total score of 215 points fell short of the 227.5-point O/U line.
Milwaukee got off to a rough start, trailing 67-43 at halftime after being outscored 34-18 in the 2nd quarter. They cut into the lead with a 33-26 3rd quarter but couldn’t complete the comeback. The Pacers went on a 10-0 run in the 4th, extending their lead from 110-95 to 120-95.
In their 98-point outing against the Pacers, the Bucks struggled offensively, shooting just 41.7% from the field and hitting only 9 threes at a 24.3% clip. Giannis Antetokounmpo led the way with 36 points and 12 rebounds, connecting on 60.9% of his shots.
AJ Green added 15 points, knocking down 5 threes at 45.5%, while Gary Trent Jr. contributed 14 points. Giannis scored 12 points in both the 1st and 3rd quarters, while Green and Trent each added 6 points in the 4th.
Defensively, the Bucks struggled in the 1st and 2nd quarters, allowing 33 and 34 points, respectively, which contributed to their 117-98 loss to the Pacers. They tightened up in the 3rd and 4th quarters, giving up 26 and 24 points, but it wasn’t enough to turn the game around.
The Pacers shot 51% from the field, including 38% from three-point range, where they hit 13 threes. The Bucks sent Indiana to the line 26 times, with the Pacers converting 20 free throws. Milwaukee gave up 5 offensive rebounds while recording 4 steals and 3 blocks.
Will the Pacers Defense Show Up at Home?
The Pacers improved to 50-32 on the season with a 117-98 win over the Bucks on Saturday, April 19th. Playing at home, Indiana was favored by 6 points and covered the spread. The game’s total points fell short of the 227.5 O/U line, with the teams combining for 215 points.
Indiana took control early, outscoring Milwaukee 34-18 in the 2nd quarter. Though the Bucks won the 3rd quarter 33-26, the Pacers entered the 4th with a 93-76 lead and went on a 10-0 run to extend their lead from 110-95 to 120-95.
Pascal Siakam led the Pacers to a win over the Bucks, scoring 25 points and grabbing 7 rebounds while shooting 66.7% from the field and hitting 3 threes at a 60% rate. Myles Turner added 19 points, connecting on 4 threes at 66.7%, and Andrew Nembhard contributed 17 points, shooting 61.5% from the field.
As a team, the Pacers shot 51.9% from the field and made 13 threes, shooting 38.2% from beyond the arc. Siakam scored 8 points in both the 1st and 4th quarters, while Turner added 9 points in the 3rd, and Nembhard scored 8 points in the 1st quarter.
The Pacers put on a strong defensive performance on Saturday, holding the Bucks to just 98 points. Indiana was particularly effective in the 2nd quarter, where they allowed only 18 points. They also limited Milwaukee to 22 points in the 4th quarter to secure the win.
Indiana held the Bucks to 41% shooting from the field and just 24% from beyond the arc, with Milwaukee making only 9 threes. The Pacers also gave up 28 free throws, with the Bucks converting 19. Indiana finished with 38 defensive rebounds, allowing 8 offensive boards, and recorded 6 steals and 6 blocks.