Michigan State Spartans vs Nebraska Cornhuskers Betting Pick & Prediction for 10/4

College Football Preview
The Michigan State Spartans are set to take on the Nebraska Cornhuskers in Week 6 of the 2025 regular season. This game will be played at Memorial Stadium in Lincoln, NE, on October 4, 2025, at 4:00 PM. Fans can catch the action on FS1. Both teams hold a record of 3-1 this season. The Spartans are looking to improve their road record after a loss away from home. Meanwhile, the Cornhuskers aim to build on their 2-1 home record in front of their fans. Both teams also have a conference record of 0-1, adding extra importance to this Big Ten matchup.

Michigan State Team Preview

The Michigan State Spartans have had a mixed start to their season. They won their first three games but faced a loss against the USC Trojans, 45-31. In that game, the Spartans had 19 first downs and 225 passing yards.

The Spartans’ offense ranks 46th in points for the season, scoring 137 points so far. Quarterback Aidan Chiles has been a key player, with 868 passing yards and 9 touchdowns. Makhi Frazier leads the rushing attack with 267 yards over four games.

The team faces some injury concerns with several players listed as questionable. Key players like Jalen Satchell and Wayne Matthews III are uncertain to play. The defense ranks 81st in points against, allowing 115 points in four games.

Michigan State vs Nebraska Game Day Info

  • Sport: NCAA Football
  • Teams: Michigan State Spartans vs Nebraska Cornhuskers
  • Venue: Memorial Stadium, Lincoln, NE
  • Date: Saturday, October 4, 2025
  • Betting Odds: Michigan State +348, Nebraska -452

Nebraska Team Preview

The Nebraska Cornhuskers have had a mixed start to the 2025 season. In their most recent game, they played against the Michigan Wolverines and lost 30-27. Despite the loss, Nebraska had more first downs with 23 compared to Michigan’s 16, and they outpaced Michigan in passing yards, 308 to 105.

Earlier in the season, the Cornhuskers had two strong wins at home. They dominated the Houston Christian Huskies with a 59-7 victory, gaining 362 passing yards and 194 rushing yards. The game against the Akron Zips was another success, ending in a 68-0 win, where Nebraska achieved 494 passing yards and 236 rushing yards.

The Cornhuskers have shown strengths in their passing game, ranking 14th in passing yards this season. Quarterback Dylan Raiola has played in all four games, leading with 1,137 passing yards and 11 touchdowns. On the ground, Emmett Johnson has been a key player, leading the team with 391 rushing yards and four touchdowns over four games.

BTB Betting Pick

For the spread pick, Nebraska is favored by 11.5 points. With Nebraska’s offense ranked 22nd in points for and Michigan State’s defense ranked 81st in points against, Nebraska is likely to cover the spread. The projected score is Nebraska 35, Michigan State 20.

For the over/under pick, the total is set at 49.5 points. Nebraska’s strong offense and Michigan State’s weaker defense suggest a higher-scoring game. The projected total is 55 points, so the recommendation is to take the over.