Louisville Cardinals vs Virginia Tech Hokies Betting Pick & Prediction for 11/1

College Football Preview

Week 10 of the 2025 NCAA Football season brings an exciting game between the Louisville Cardinals and the Virginia Tech Hokies. This game takes place at Lane Stadium in Blacksburg, VA, on Saturday, November 1, 2025, at 3:00 PM. Fans can catch the action on the CW channel.

Louisville enters the game ranked #16 in the AP Poll with a strong 6-1 record. The Cardinals have been solid on the road with a 2-0 record. On the other side, Virginia Tech has a 3-5 record this season, with a 2-4 record at home. Both teams are part of the Atlantic Coast Conference, adding more intensity to this matchup.

Louisville Team Preview

The Louisville Cardinals have been performing well this season. In their recent games, they secured a 38-24 win against Boston College. They achieved 319 rushing yards in that game, showing strength on the ground.

Quarterback Miller Moss has been a key player for the Cardinals. Over seven games, he has accumulated 1,793 passing yards and 10 touchdowns. Running back Isaac Brown has also been impactful, gaining 652 rushing yards over seven games.

The Cardinals have a few players dealing with injuries. Stanquan Clark is out for the season due to ankle surgery. Several others, including Travis Egan and Kris Hughes, are listed as questionable with undisclosed injuries.

Louisville vs Virginia Tech Game Day Info

  • Sport: NCAA Football
  • Teams: Louisville Cardinals vs. Virginia Tech Hokies
  • Venue: Lane Stadium in Blacksburg, VA
  • Date: Saturday, November 1, 2025 at 3:00 PM
  • Betting Odds: Louisville Moneyline -417, Virginia Tech Moneyline +321, Louisville Spread -10.5 (-110), Virginia Tech Spread +10.5 (-110), Total Over 53.5 (-113), Total Under 53.5 (-108)

Virginia Tech Team Preview

The Virginia Tech Hokies have shown strength in their recent games. Their latest victory against the California Golden Bears with a score of 42-34 highlights their offensive power. The Hokies gained 358 rushing yards in that game, which was a key factor in their win at Lane Stadium.

Virginia Tech’s season stats reflect a strong rushing offense. They rank 32nd in rushing yards with 1,495 yards this season. Their defense has been a challenge, ranking 120th in points against, allowing 239 points so far.

The Hokies have some injury concerns. Several players are listed as questionable with undisclosed issues, including Braydon Bennett and James Jennette. Keeping these players healthy will be important for Virginia Tech’s success in upcoming games.

BTB Betting Pick

For the spread pick, take Louisville to cover -10.5. Louisville’s offense has scored 242 points this season, ranking 41st, while Virginia Tech has given up 239 points, ranking 120th in defense. The projected score is Louisville 35, Virginia Tech 21, which supports the spread pick.

For the over/under pick, go with the under 53.5. Louisville’s defense has allowed 150 points this season, ranking 69th, and Virginia Tech’s offense has scored 203 points, ranking 64th. With a projected total score of 56, the under is a safer bet considering the defensive capabilities.