Louisville Cardinals vs Clemson Tigers NCAAB Betting Pick & Prediction for 2/28

The Louisville Cardinals, ranked #24, will travel to face the Clemson Tigers on Saturday, February 28, 2026. The game is set for 2:00 PM ET at Littlejohn Coliseum in Clemson, SC. This is an Atlantic Coast Conference matchup, and it will be aired on ESPN2.

The Cardinals are favored by 1.5 points with a moneyline of -124. They have a season record of 20-8, with an away record of 6-6. The Tigers have the same overall record of 20-8 and a home record of 11-3. Clemson is the underdog with a moneyline of +101. The over/under for the game is set at 146.5 points.

Louisville Cardinals vs Clemson Tigers Game Day Info

  • Sport: College Basketball
  • Teams: Louisville Cardinals vs Clemson Tigers
  • Venue: Littlejohn Coliseum, Clemson SC
  • Date: Saturday, February 28, 2026
  • Betting Odds: Louisville Spread -1.5 (-110), Clemson Spread +1.5 (-113), Louisville MoneyLine -124, Clemson MoneyLine +101, Over/Under 146.5

Louisville Cardinals Team Preview

The Louisville Cardinals hold a record of 20-8 for the season. They rank 24th in the AP poll and play in the Atlantic Coast Conference. Their performance away from home stands at 6-6, showing room for improvement on the road.

In recent games, Louisville scored an average of 82 points. Against North Carolina, they lost by 3 points with a score of 74-77. Their shooting was 38.8% from the field in that game.

Key players include Ryan Conwell and Mikel Brown Jr., who have consistently scored in double digits. Conwell averages 18.5 points per game, while Brown Jr. averages 18.9. J’Vonne Hadley also contributes with 11.3 points and 5.2 rebounds per game.

Clemson Tigers Team Preview

The Clemson Tigers have had a tough run in their recent games. They have lost their last three games, including a close 65-70 loss against Florida State. In this game, Ace Buckner led with 15 points and added four rebounds and three assists.

In their game against Wake Forest, the Tigers scored 77 points but fell short by eight. Jake Wahlin made a strong impact with 17 points and five rebounds. Despite their efforts, Clemson struggled to keep up with Wake Forest’s pace.

The Tigers’ game against Duke ended in a 54-67 loss. Clemson’s field goal percentage was low, hitting only 35.1% of their shots. RJ Godfrey was a standout player with 10 points and eight rebounds, but the team couldn’t overcome Duke’s defense.

BTB Betting Pick

For the spread pick, Louisville is favored by 1.5 points. Louisville scores 86.4 points per game, much higher than Clemson’s 74.5 points per game. With Louisville’s strong offense, picking Louisville to cover the -1.5 spread is a reasonable choice. The projected score is Louisville 82, Clemson 75.

For the over/under pick, the line is set at 146.5. Louisville’s fast pace and high scoring ability suggest a high-scoring game. Clemson’s lower scoring may not keep up, but Louisville’s offense should push the total over 146.5. The projected total is 157 points, so the recommendation is to take the over.