Louisville Cardinals vs Cincinnati Bearcats NCAAB Betting Pick & Prediction for 11/21

The #6 Louisville Cardinals will take on the Cincinnati Bearcats on Friday, November 21, 2025. The game will be held at the Heritage Bank Center in Cincinnati, Ohio. This non-conference game features two teams that are both undefeated with a 4-0 record this season.

Louisville enters the game as the favorite with a spread of -8.5 and a MoneyLine of -507. The Cardinals have shown strong performance, especially from players like Ryan Conwell and Mikel Brown Jr. Cincinnati, with a spread of +8.5 and a MoneyLine of +351, will look to challenge Louisville with key players such as Baba Miller and Day Day Thomas. The game will be broadcast on ESPN2.

Louisville Cardinals vs Cincinnati Bearcats Game Day Info

  • Sport: College Basketball
  • Teams: Louisville Cardinals vs Cincinnati Bearcats
  • Venue: Heritage Bank Center, Cincinnati OH
  • Date: Friday, November 21, 2025 at 6:30 PM ET
  • Betting Odds:
    • Louisville Spread: -8.5 (-113)
    • Cincinnati Spread: +8.5 (-108)
    • Louisville MoneyLine: -507
    • Cincinnati MoneyLine: +351
    • Over/Under: 163.5 (-110)

Louisville Cardinals Team Preview

The Louisville Cardinals are off to a strong start this season. They have won their first four games. In their latest outing, they defeated the Ohio Bobcats 106-81.

The Cardinals are known for their offensive power. They rank second in points per game, averaging 103.0. They also have impressive stats in three-point shooting, making 12.8 per game.

Key players like Ryan Conwell and Mikel Brown Jr. have been consistent. Conwell averages 19.2 points per game, while Brown Jr. also averages 19.2. Both players have played significant roles in their recent victories.

Cincinnati Bearcats Team Preview

The Cincinnati Bearcats have been strong at home this season. They won their last three games against Mount St. Mary’s, Dayton, and Georgia State. The team is currently 4-0, showing they perform well in their home environment.

The Bearcats average 78.5 points per game, which ranks them 213th. Their field goal percentage is 44.3, while their three-point percentage is lower at 29.9. They are effective at drawing fouls, with 19.5 free throws made per game, ranking 61st.

Key players include Baba Miller and Day Day Thomas. Miller averages 15.8 points and 10.5 rebounds per game. Thomas contributes with 14 points and 3.5 rebounds, providing strong support to the team’s efforts.

BTB Betting Pick

For the spread pick, Louisville is favored by 8.5 points. With their high offensive output of 103.0 points per game, they are likely to cover the spread against Cincinnati, who scores 78.5 points per game. The projected score is Louisville 97, Cincinnati 81, suggesting Louisville will win by more than 8.5 points.

For the over/under pick, the line is set at 163.5 points. Louisville’s high-scoring games and Cincinnati’s moderate scoring suggest a total score of around 178 points. Given this projection, the recommendation is to take the over at 163.5 points.