Los Angeles Chargers vs Dallas Cowboys Betting Pick & Prediction for 12/21

The Los Angeles Chargers travel to face the Dallas Cowboys in Week 16 of the 2025 NFL season. The game is set for Sunday, December 21, at 1:00 PM at AT&T Stadium in Arlington, Texas. With the retractable roof, weather should not impact the game, and conditions are expected to be clear and mild.

The Chargers come into this game with a strong 10-4 record, including a 4-2 mark on the road. Led by head coach Jim Harbaugh, they have been solid in the AFC West. On the other hand, the Cowboys, coached by Brian Schottenheimer, hold a 6-7-1 record. They have performed better at home with a 4-2-1 record, and they aim to capitalize on home advantage.

Los Angeles Chargers Team Preview

The Los Angeles Chargers have been on a roll lately. In their recent game against the Kansas City Chiefs, they won 16-13. Justin Herbert led the team with 210 passing yards and a touchdown.

In another strong performance, the Chargers defeated the Las Vegas Raiders 31-14. Kimani Vidal stood out with 126 rushing yards and a touchdown. The team’s defense also did well, limiting the Raiders to just 12 first downs.

However, not all games have been easy for the Chargers. They faced a tough loss against the Jacksonville Jaguars, losing 35-6. Despite the defeat, Keenan Allen managed to grab 53 receiving yards.

Chargers vs Cowboys Game Day Info

• Sport: NFL
• Teams: Los Angeles Chargers vs. Dallas Cowboys
• Venue: AT&T Stadium in Arlington, TX
• Date: Sunday, December 21, 2025
• Betting Odds: Chargers +109, Cowboys -129, Spread: Chargers +2.0 (-111), Cowboys -2.0 (-108), Total: Over 49.5 (-112), Under 49.5 (-108)

Dallas Cowboys Team Preview

The Dallas Cowboys are playing at home this week. They have had mixed results in their recent home games. They won against the Kansas City Chiefs 31-28 and Philadelphia Eagles 24-21, but lost to the Minnesota Vikings 34-26.

Dak Prescott leads the team in passing yards with 3,931 this season. Javonte Williams is a key player in rushing, gaining 1,113 yards. George Pickens stands out in receiving with 1,212 yards.

The Cowboys face injury issues, with several players on injured reserve. Miles Sanders is out for the season with a knee and ankle injury. Trevon Diggs is questionable with a concussion and knee issue.

BTB Betting Pick

The Chargers are the pick to cover the spread at +2.0 (-111). Their defense ranks 1st in opponent scoring, allowing only 301 points. The Cowboys’ defense ranks 28th, having allowed 468 points. This defensive edge should help the Chargers keep the game close or win outright.

The total for the game is set at 49.5. The Chargers’ defense is strong, and they have allowed fewer points than any other team. The Cowboys’ offense ranks 20th in scoring, which suggests a lower-scoring game. The recommendation is to take the under 49.5 (-108), as the projected total score is likely to be less than the line.