Jacksonville Jaguars vs Indianapolis Colts Betting Pick & Prediction for 12/28

NFL Game preview

The Jacksonville Jaguars are set to take on the Indianapolis Colts in Week 17 of the 2025 NFL season. The game will be held at Lucas Oil Stadium in Indianapolis. Kickoff is scheduled for Sunday, December 28 at 1:00 PM, and fans can catch the action on FOX.

Jacksonville comes into the game with an 11-4 record, while the Colts hold an 8-7 record. Both teams are part of the AFC South division. The weather forecast for the day predicts a very cold day with broken clouds, but the retractable roof at the stadium should minimize the impact of the weather. The Jaguars are favored with a moneyline of -290, and the Colts are at +235.

Jacksonville Jaguars Team Preview

The Jacksonville Jaguars have been strong in recent games. Trevor Lawrence led the team with 279 passing yards and three touchdowns against the Denver Broncos. They won 34-20, securing 22 first downs and holding the Broncos to one interception and one fumble.

In their game against the New York Jets, the Jaguars scored 48 points. Lawrence had another impressive performance with 330 passing yards and five touchdowns. The Jaguars’ defense was solid, forcing three interceptions and allowing only 154 passing yards.

Travis Etienne Jr. has been a key player for the Jaguars. He rushed for 74 yards and two touchdowns in their game against the Indianapolis Colts. Despite two fumbles, the Jaguars won 36-19, with their defense recording two interceptions and holding the Colts to 196 passing yards.

Jaguars vs Colts Game Day Info

  • Sport: NFL
  • Teams: Jacksonville Jaguars vs. Indianapolis Colts
  • Venue: Lucas Oil Stadium in Indianapolis, IN USA
  • Date: Sunday, December 28, 2025 at 1:00 PM
  • Betting Odds: Jaguars Moneyline -290, Colts Moneyline +235, Jaguars Spread -6.5 (-114), Colts Spread +6.5 (-107), Total Over 48.5 (-107), Total Under 48.5 (-115)

Indianapolis Colts Team Preview

The Indianapolis Colts have struggled recently, dropping their last five games. In their most recent game, the Colts lost to the San Francisco 49ers 48-27. Their offense managed 254 passing yards, but only 58 rushing yards, showing a need for balance.

The Colts have faced challenges on defense, allowing a high number of points and yards in recent games. Against the 49ers, they allowed 295 passing yards and 145 rushing yards. Their defense did manage to snag an interception, but they still need to tighten up to stop their opponents more effectively.

Key players for the Colts include running back Jonathan Taylor and wide receiver Alec Pierce. Taylor has been a standout with 1,489 rushing yards this season. Pierce has also been a strong performer, contributing significantly in recent games with multiple touchdown receptions.

BTB Betting Pick

The Jaguars are favored by 6.5 points against the Colts. Considering the Jaguars’ defense, which ranks 25th in opponent scoring, the Colts could keep it close. The pick is Colts +6.5, with a projected score of Jaguars 27, Colts 24.

The total for the game is set at 48.5 points. Both teams have struggled defensively, with the Jaguars allowing 435 points and the Colts 427 last season. Expect a high-scoring game, so the pick is Over 48.5.