Jacksonville Jaguars vs Arizona Cardinals Betting Pick & Prediction for 11/23

The Jacksonville Jaguars will head to Arizona to play the Cardinals at State Farm Stadium. The game is scheduled for Sunday, November 23, 2025, at 4:05 PM. Fans can watch the game on CBS.

The Jaguars have a season record of 6-4-0, with a 2-2-0 road record. They are coached by Liam Coen. The Cardinals have a season record of 3-7-0 and a home record of 1-4-0. Jonathan Gannon is the head coach for the Cardinals. The weather in Glendale is expected to be mild, but the retractable roof at the stadium will minimize any impact from the wind.

Jacksonville Jaguars Team Preview

The Jacksonville Jaguars recently won big against the Los Angeles Chargers, 35-6. Trevor Lawrence led the team with 153 passing yards and one touchdown. Travis Etienne Jr. was key in rushing with 73 yards and two touchdowns.

In a close game against the Houston Texans, the Jaguars lost 36-29. Trevor Lawrence threw for 158 yards with one touchdown and one interception. Travis Etienne Jr. contributed with 58 rushing yards and one touchdown.

The Jaguars have dealt with injuries this season. Key players like Travis Hunter and Eric Murray are out for the rest of the season. Others, like Bhayshul Tuten and Brian Thomas Jr., are questionable for the upcoming game.

Jaguars vs Cardinals Game Day Info

• Sport: NFL
• Teams: Jacksonville Jaguars vs. Arizona Cardinals
• Venue: State Farm Stadium in Glendale, AZ
• Date: Sunday, November 23, 2025
• Betting Odds: Jaguars Moneyline -149, Cardinals Moneyline +125, Jaguars Spread -2.5 (-116), Cardinals Spread +2.5 (-104), Total Over/Under 47.5 (-110)

Arizona Cardinals Team Preview

The Arizona Cardinals have struggled recently, losing their last two games. In their last home game against the San Francisco 49ers, they lost 41-22. Despite the loss, Jacoby Brissett threw for 452 yards and two touchdowns, but he also had two interceptions.

The Cardinals’ offense has been inconsistent, as seen in their loss to the Seattle Seahawks, where they scored 22 points. They had 206 passing yards and 129 rushing yards in that game. Trey McBride was a bright spot with 127 receiving yards and a touchdown.

Injury issues have affected the Cardinals, with several key players out. Kyler Murray is out with a foot injury, and Marvin Harrison Jr. is questionable. The team needs to manage these injuries to improve their performance in upcoming games.

BTB Betting Pick

The Jaguars are favored by 2.5 points against the Cardinals. The Jaguars have struggled on both offense and defense, ranking low in scoring and opponent scoring. Meanwhile, the Cardinals have a stronger offense, ranking 12th in scoring. With the Cardinals playing at home and having a better offensive and defensive ranking, taking the Cardinals to cover the +2.5 spread seems like a solid pick.

The total for the game is set at 47.5 points. The Jaguars’ defense ranks 25th in points allowed, while the Cardinals’ offense ranks 12th in scoring. However, the Cardinals’ defense is better, ranked 14th in points allowed. The projected score suggests a close game, potentially under the total. Thus, the under 47.5 is the recommendation for this game.