Iowa Hawkeyes vs USC Trojans Betting Pick & Prediction for 11/15

College Football Preview

In Week 12 of the 2025 regular season, the Iowa Hawkeyes will travel to face the USC Trojans. The game is set for Saturday, November 15, at the Los Angeles Memorial Coliseum. Fans can catch the action at 3:30 PM on BTN.

The Iowa Hawkeyes come into this game with a 6-3 record. They have performed well on the road, holding a 2-1 record. Meanwhile, the USC Trojans stand at 7-2 and have remained undefeated at home with a 5-0 record. Both teams are part of the Big Ten Conference.

Iowa Team Preview

The Iowa Hawkeyes have had a mixed season so far. They have won games against teams like Minnesota and Wisconsin. However, they have also faced losses against Oregon and Indiana.

On offense, the Hawkeyes have scored 266 points this season. Their passing game ranks 131st, with Mark Gronowski leading the team. The rushing attack is stronger, ranking 44th in the nation.

Defensively, Iowa has allowed 123 points, ranking 52nd. They have 17 sacks, which places them 17th. Key players include those recovering 2 fumbles and securing 10 interceptions.

Iowa vs USC Game Day Info

  • Sport: NCAA Football
  • Teams: Iowa Hawkeyes vs USC Trojans
  • Venue: Los Angeles Memorial Coliseum in Los Angeles, CA
  • Date: Saturday, November 15, 2025
  • Betting Odds: Iowa +207, USC -253

USC Team Preview

USC Trojans have shown strong performance at home this season. In their recent game against Northwestern, they won 38-17 at the Los Angeles Memorial Coliseum. The Trojans tallied 24 first downs and 309 passing yards in that game.

In their recent away games, the Trojans had mixed results. They secured a 21-17 win against Nebraska but fell to Notre Dame 34-24. The Trojans had a notable passing game against Notre Dame, recording 328 yards.

USC’s offense ranks 11th in points for and 15th in passing yards for the season. Their defense stands out with 24 sacks, ranking 10th. However, they face some challenges with injuries, including Eli Sanders out for the season with a knee injury.

BTB Betting Pick

The current spread has USC favored by 6.5 points. Iowa’s defense has been strong, allowing only 123 points this season, ranking 52nd. Given Iowa’s defensive performance, taking Iowa +6.5 is a reasonable pick as they may keep the game close against USC.

The total for the game is set at 49.5 points. Iowa’s offense has struggled, ranking 131st in passing yards, while their defense ranks 52nd in points against. USC’s offense is strong, but Iowa’s defense could keep the score lower. Therefore, the under 49.5 points is a good choice.