Indiana Hoosiers vs Purdue Boilermakers Betting Pick & Prediction for 11/28

College Football Preview

Week 14 of the 2025 NCAA football season brings the Indiana Hoosiers to Ross-Ade Stadium. They will play against the Purdue Boilermakers in West Lafayette, IN. This night game is set for Friday, November 28, at 7:30 PM and will be broadcast on NBC.

The Indiana Hoosiers come into this game ranked #2 in both the AP and Coaches Polls. They have an impressive 11-0 record this season. On the other hand, the Purdue Boilermakers have struggled, holding a 2-9 record with no conference wins. The odds favor Indiana heavily, with a moneyline of -7900, while Purdue stands at +1900.

Indiana Team Preview

Indiana Hoosiers have shown strong performance in their recent games. They defeated Wisconsin 31-7, with 305 passing yards and 83 rushing yards. Their defense was solid, allowing only 98 passing yards and 70 rushing yards to Wisconsin.

In the game against Penn State, Indiana managed a close 27-24 win. They gained 218 passing yards and 108 rushing yards. Indiana forced two fumbles from Penn State, which helped secure their victory.

The Hoosiers dominated Maryland with a 55-10 win, showcasing their rushing game with 369 yards. Their defense restricted Maryland to just 37 rushing yards. Indiana forced three fumbles in that game, highlighting their defensive strength.

Indiana vs Purdue Game Day Info

  • Sport: NCAA Football
  • Teams: Indiana Hoosiers vs. Purdue Boilermakers
  • Venue: Ross-Ade Stadium in West Lafayette, IN
  • Date: Friday, November 28, 2025
  • Betting Odds: Indiana Moneyline -7900, Purdue Moneyline +1900, Indiana Spread -28.5 (-109), Purdue Spread +28.5 (-111), Total Over 54.5 (-108), Total Under 54.5 (-112)

Purdue Team Preview

The Purdue Boilermakers have had a challenging season. In their recent game against the Washington Huskies, they fell short with a 49-13 loss. Purdue struggled to gain ground, recording only 167 passing yards and 100 rushing yards.

In a home game against the Ohio State Buckeyes, Purdue faced another setback. The Buckeyes won 34-10, and Purdue managed 94 passing yards and 92 rushing yards. Despite their efforts, the Boilermakers struggled to match Ohio State’s 30 first downs.

Purdue’s quarterback, Ryan Browne, has played 11 games this season. He has passed for 1,915 yards with nine touchdowns. Injuries have affected the team, with key players like Devin Mockobee and Chauncey Magwood out for the season.

BTB Betting Pick

For the spread pick, Indiana is favored by 28.5 points. Indiana has a strong offense, ranking 2nd in points scored this season. Purdue’s defense ranks 127th in points allowed. The projected score is Indiana 45, Purdue 17. Indiana should cover the spread of -28.5 (-109).

For the over/under pick, the total is set at 54.5 points. Indiana’s offense is powerful, while Purdue struggles on defense. The projected total score is 62 points. The recommendation is to take the over at 54.5 (-108).