Florida Gators vs Ole Miss Rebels Betting Pick & Prediction for 11/15

Week 12 of the 2025 NCAA Football season brings the Florida Gators to face the Ole Miss Rebels at Vaught-Hemingway Stadium. The game is set for Saturday, November 15, at 7:00 PM. Fans can catch the action on ESPN.
The Florida Gators come into this game with a 3-6 record, struggling on the road with no wins. Ole Miss, ranked #6 in the AP poll, boasts a strong 9-1 record and remains unbeaten at home. The odds show Ole Miss as the favorite, with a spread of -16.5.
Florida Team Preview
The Florida Gators have had a tough season so far. They lost to the Kentucky Wildcats 38-7. In that game, the Gators struggled with their ground defense, allowing 235 rushing yards.
DJ Lagway leads the Gators as the quarterback. He has played nine games with 1,464 passing yards. He has thrown nine touchdowns but also has 11 interceptions.
The Gators’ defense has been strong in some areas. They have recovered six fumbles and grabbed six interceptions. However, they have allowed 202 points this season, ranking them 85th.
Florida vs Ole Miss Game Day Info
- Sport: NCAA Football
- Teams: Florida Gators vs. Ole Miss Rebels
- Venue: Vaught-Hemingway Stadium, Oxford, MS
- Date: Saturday, November 15, 2025
- Betting Odds: Florida Moneyline +506, Ole Miss Moneyline -728, Florida Spread +16.5 (-113), Ole Miss Spread -16.5 (-106), Total Over 53.5 (-112), Total Under 53.5 (-109)
Ole Miss Team Preview
The Ole Miss Rebels have been strong this season. They recently won against The Citadel Bulldogs, 49-0. In that game, they had 452 passing yards and 151 rushing yards.
Trinidad Chambliss is a key player for the Rebels. He leads with 2,356 passing yards and 13 touchdowns this season. Kewan Lacy is their top rusher with 912 yards and 16 touchdowns.
Defensively, the Rebels have allowed 198 points this season. They have 21 sacks and 5 interceptions. Antonio Kite is questionable for the next game due to an undisclosed injury.
BTB Betting Pick
The spread for the game is Ole Miss -16.5. Ole Miss has a strong offense, ranking 7th in points for this season. Florida’s defense is ranked 85th in points against, which may struggle against Ole Miss’s top-ranked passing game. The projected score is Ole Miss 38, Florida 17. The recommendation is to pick Ole Miss to cover the spread at -16.5.
The total for the game is set at 53.5. Ole Miss has a high-scoring offense, but Florida’s offense ranks 87th in points for. Considering Florida’s struggles to score and their defense’s ability to force turnovers, the projected total is 55 points. The recommendation is to take the over at 53.5.