Connecticut Huskies vs DePaul Blue Demons NCAAB Betting Pick & Prediction for 12/21

The Connecticut Huskies will take on the DePaul Blue Demons at Wintrust Arena in Chicago. The game is set for Sunday, December 21, 2025, at 4:30 PM ET. This Big East conference game will be aired on FS1.

Connecticut enters the game ranked #5 with an 11-1 record this season. DePaul holds an 8-4 record and will look to defend their home court. The Huskies are favored by 14.5 points, with an over/under set at 136.5 points.

Connecticut Huskies vs DePaul Blue Demons Game Day Info

  • Sport: College Basketball
  • Teams: Connecticut Huskies vs DePaul Blue Demons
  • Venue: Wintrust Arena, Chicago IL
  • Date: Sunday, December 21, 2025 at 4:30 PM ET
  • Betting Odds: Connecticut Huskies Spread -14.5 (-110), DePaul Blue Demons Spread +14.5 (-110), Connecticut Huskies MoneyLine -1500, DePaul Blue Demons MoneyLine +850, Over/Under 136.5 (-112/-109)

Connecticut Huskies Team Preview

The Connecticut Huskies have been performing well this season. They hold a record of 11-1 and are ranked #5 in the AP rankings. Their away record is perfect, standing at 3-0.

On offense, the Huskies score an average of 79.0 points per game. Their field goal percentage is strong at 49.7%, placing them 36th in the nation. They also excel in assists, averaging 18.4 per game, which ranks 32nd.

Defensively, the team records 7.2 steals per game. However, they struggle with fouls, committing 18.5 per game. In recent games, players like Solo Ball and Alex Karaban have been key contributors on both ends of the court.

DePaul Blue Demons Team Preview

The DePaul Blue Demons have a record of 8-4 this season. They have played well at home with a 7-3 record, showing strength in familiar settings. In their conference, the Big East, they have been competitive with various results.

Offensively, DePaul scores an average of 76.4 points per game. They have a field goal percentage of 45.3%, which places them in the middle range compared to other teams. The Blue Demons make around 17.2 free throws per game, which ranks them 95th in the nation.

On defense, DePaul gets about 7.3 steals per game. They also have a turnovers per game stat of 11.2, which they aim to improve. Fouls have been an issue, as they commit 18.2 fouls per game, ranking them low nationally.

BTB Betting Pick

Connecticut is favored by 14.5 points against DePaul. Connecticut scores 79.0 points per game, while DePaul scores 76.4 points per game. The spread pick is Connecticut -14.5. Connecticut’s higher field goal percentage and stronger assist numbers suggest they can cover the spread.

The over/under for the game is set at 136.5 points. Connecticut and DePaul combine for an average of 155.4 points per game. The pick is over 136.5. Both teams have decent offensive stats, which indicates the total could exceed the set line.