Colorado State Rams vs Wyoming Cowboys Betting Pick & Prediction for 10/25
This article was published on Oct 21, 2025. Today’s picks College Football picks

The Colorado State Rams will travel to Laramie to take on the Wyoming Cowboys in Week 9 of the 2025 regular season. This Mountain West Conference game will be held at War Memorial Stadium on Saturday, October 25, at 7:30 PM. Fans can catch the action on CBSS.
Colorado State comes into this game with a 2-5 record, looking for their first road win. Wyoming holds a 3-4 record and aims to improve their home performance, which stands at 2-2. The betting odds favor Wyoming with a moneyline of -228 and a spread of -6.0.
Colorado State Team Preview
The Colorado State Rams have had mixed results this season. They won a big game against the Fresno State Bulldogs with a score of 49-21. However, they lost to the Hawaii Rainbow Warriors, San Diego State Aztecs, and Washington State Cougars in their recent games.
Offensively, the Rams rank 102nd in passing yards and 71st in rushing yards this season. Jackson Brousseau leads the team in passing with 741 yards and six touchdowns. On the ground, Jalen Dupree is the top rusher with 429 yards and two touchdowns.
Defensively, the Rams are ranked 102nd in points against. They have shown strength in forcing turnovers with seven interceptions and three fumbles recovered. Injuries have been a challenge, with key players like Mukendi Wa-Kalonji and Stephon Daily out for the season.
Colorado State vs Wyoming Game Day Info
- Sport: NCAA Football
- Teams: Colorado State Rams vs. Wyoming Cowboys
- Venue: War Memorial Stadium (WY) in Laramie, WY
- Date: Saturday, October 25, 2025
- Betting Odds:
- Colorado State Moneyline: +189
- Wyoming Moneyline: -228
- Colorado State Spread: +6.0 (-109)
- Wyoming Spread: -6.0 (-111)
- Total Over: 46.5 (-111)
- Total Under: 46.5 (-110)
Wyoming Team Preview
The Wyoming Cowboys have had a mix of results this season. In their recent game, they played against Air Force Falcons and lost 24-21. Despite their loss, they showed strong passing skills with 211 passing yards compared to Air Force’s 33 yards.
In their victory against San Jose State Spartans, the Cowboys scored 35-28. The team excelled in passing with 304 yards. Their rushing game also contributed with 109 yards on the ground.
Wyoming’s season has been challenging with a series of losses. They fell to teams like UNLV and Utah with scores of 31-17 and 31-6 respectively. Injuries have also impacted the team, with several players out for the season.
BTB Betting Pick
The current spread for the game is Wyoming -6.0. Given the stats, Wyoming has a better defense with only 158 points against, compared to Colorado State’s 189. With this defensive edge, Wyoming is projected to win 28-20. This makes Wyoming a good pick to cover the spread.
The total for the game is set at 46.5. Colorado State and Wyoming have scored a combined 293 points this season. This averages out to about 42 points per game. With both teams having solid defenses, the projected total is 48, suggesting taking the over is a reasonable choice.