Colorado Buffaloes vs TCU Horned Frogs Betting Pick & Prediction for 10/4

College Football Preview

Week 6 of the 2025 regular season features the Colorado Buffaloes visiting the TCU Horned Frogs. The game is set to take place at Amon G. Carter Stadium in Fort Worth, Texas. Fans can catch the action on FOX at 7:30 PM on Saturday, October 4, 2025.

The Buffaloes hold a 2-3 record this season, with struggles on the road as they stand 0-1 away from home. In contrast, the Horned Frogs have a 3-1 record and remain undefeated at home with a 2-0 streak. Both teams are part of the Big 12 conference, adding to the excitement of this matchup.

Colorado Team Preview

The Colorado Buffaloes have had a mixed start to their 2025 season. They have two wins and three losses so far. Their victories came against Wyoming and Delaware, with scores of 37-20 and 31-7 respectively.

Offensively, the Buffaloes have put up 129 points this season, ranking 51st. Their passing game has been strong, with 1,053 yards, placing them 64th. Kaidon Salter, their top quarterback, has thrown for 684 yards in four games.

The Buffaloes are dealing with several injuries, which could impact their performance. Players like Tyler Brown and Sav’ell Smalls are out. Meanwhile, Kaidon Salter and Preston Hodge are probable to play despite their injuries.

Colorado vs TCU Game Day Info

  • Sport: NCAA Football
  • Teams: Colorado Buffaloes vs. TCU Horned Frogs
  • Venue: Amon G. Carter Stadium in Fort Worth, TX
  • Date: Saturday, October 4, 2025
  • Betting Odds: Colorado Moneyline +401, TCU Moneyline -539, Colorado Spread +13.5 (-108), TCU Spread -13.5 (-112), Total Over 58.0 (-113), Total Under 58.0 (-107)

TCU Team Preview

The TCU Horned Frogs have had a mixed start to their season. They have a record of 3-1, showing strong performances at home. They defeated SMU 35-24 and Abilene Christian 42-21 at Amon G. Carter Stadium.

Quarterback Josh Hoover is having a great season. He has 1,242 passing yards and 11 touchdowns in four games. His efforts rank him first on the team in several categories.

Injuries are a concern for TCU. Key players like Kevorian Barnes and Kyle Lemmermann are out. Several others are questionable, which could impact the team’s performance.

BTB Betting Pick

For the spread pick, consider taking TCU to cover -13.5. TCU has scored 149 points this season, ranking 35th, while Colorado has allowed 114 points, ranking 80th. With TCU’s strong offense and Colorado’s weaker defense, the projected score is TCU 38, Colorado 21, making TCU a solid choice to cover.

For the over/under pick, the recommendation is to take the over 58.0. TCU and Colorado have combined for a total of 278 points this season. Both teams have shown the ability to score, and the projected total points are 59, suggesting the over is a good option.