Cincinnati Reds vs Tampa Bay Rays Betting Pick & Prediction for 4/22

MLB game preview

The Cincinnati Reds travel to Tropicana Field to take on the Tampa Bay Rays. The game is part of the MLB regular season. The Reds currently hold a record of 16-8, sitting at the top of the NL Central Division. They are on a five-game winning streak and have an impressive road record of 10-2. The game is set for Wednesday, April 22, 2026, at 1:10 PM.

The Tampa Bay Rays have a record of 12-11 and are in second place in the AL East Division. They have lost their last three games. Nick Martinez will be starting on the mound for the Rays, sporting a 2.45 ERA. The game will be broadcast on the RAYS channel. Despite the dome setting, the weather forecast calls for mild conditions with broken clouds outside.

Cincinnati Reds Team Preview

The Cincinnati Reds have shown strong performances in their recent games. On April 21st, they defeated the Tampa Bay Rays with a score of 12-6. Elly De La Cruz was a standout player, hitting two home runs and driving in five runs. Chase Burns also contributed with a solid start, pitching 5 2/3 innings and striking out eight batters.

In the game on April 20th, the Reds secured another win against the Rays, 6-1. Rhett Lowder pitched well, allowing only one earned run over six innings. Sal Stewart made an impact at the plate with a home run and two RBIs, helping the team maintain their winning streak.

The Reds have a batting average of .207 this season, ranking 24th in the league. However, they have hit 27 home runs, which ranks them 6th. On the mound, they have an ERA of 3.47, placing them 9th in the league. Brandon Williamson will be their starting pitcher in the upcoming game, bringing a record of 2-1 and an ERA of 4.35.

Reds vs Rays Game Day Info

  • Sport: MLB
  • Teams: Cincinnati Reds vs. Tampa Bay Rays
  • Venue: Tropicana Field in St. Petersburg, FL
  • Date: Wednesday, April 22, 2026
  • Betting Odds: Reds Moneyline +117, Rays Moneyline -140

Tampa Bay Rays Team Preview

The Tampa Bay Rays are struggling in recent games. They have lost four of their last five games. Their latest loss was a 12-6 defeat against the Cincinnati Reds.

The Rays’ hitting is ranked fourth in batting average at .255. Their on-base percentage is .327, placing them 11th. They have hit 19 home runs this season, which is 10th in the league.

On the pitching side, the Rays have a team ERA of 4.91, which ranks 27th. They have given up 33 home runs, placing them 16th. Nick Martinez, with an ERA of 2.45, is set to start the next game for the Rays.

BTB Betting Pick

The Rays are favored to win against the Reds with a moneyline of -140. The Rays have a strong batting average of .255, ranking 4th in the league, while the Reds rank 24th with a .207 average. Considering these stats, the pick is for the Rays to win the game with a projected score of 5-3.

The total for the game is set at 8.0 runs. The Reds have an earned run average of 4.91, which is 27th in the league, indicating potential for high scoring. The Rays’ earned run average is better at 3.47, ranking 9th. Given these factors, the recommendation is to take the over, expecting a combined total score of more than 8 runs.