Chicago Cubs vs Chicago White Sox Betting Pick & Prediction for 5/16

MLB game preview

The Chicago Cubs will visit the Chicago White Sox at Rate Field. The game is set for Saturday, May 16, 2026, at 7:10 PM. Fans can catch the action on MARQ.

The Cubs lead the NL Central with a 29-16 record. They have a two-game winning streak. The White Sox hold a 22-22 record and are second in the AL Central. They are coming off a loss in their last game.

Chicago Cubs Team Preview

The Chicago Cubs have been on the road recently, with varying results. They had a strong win against the Chicago White Sox, scoring 10 runs with 14 hits. Carson Kelly stood out with 4 RBIs, contributing significantly to the win.

In their game against the Atlanta Braves on May 14th, the Cubs secured a 2-0 victory. Ben Brown delivered an impressive performance on the mound, allowing only 1 hit in 4 innings. Ian Happ’s home run was key in this low-scoring game.

The Cubs’ offense struggled in the May 13th game, resulting in a 4-1 loss to the Braves. They managed only 4 hits and no extra-base hits during the game. Shota Imanaga pitched well, but the lack of run support made it difficult for the team to win.

Cubs vs White Sox Game Day Info

  • Sport: MLB
  • Teams: Chicago Cubs vs. Chicago White Sox
  • Venue: Rate Field in Chicago, IL
  • Date: Saturday, May 16, 2026
  • Betting Odds: Cubs Moneyline -113, White Sox Moneyline -106

Chicago White Sox Team Preview

The Chicago White Sox have shown mixed results in recent games. They lost to the Chicago Cubs on May 15th with a score of 10-5. In that game, the White Sox hit three home runs, but the Cubs out-hit them with 14 hits overall.

On May 14th, the White Sox secured a 6-2 win against the Kansas City Royals. Randal Grichuk was a key player, going 2 for 3 with a home run and four RBIs. The White Sox’s pitching was solid with Anthony Kay allowing only two earned runs over six innings.

In their game on May 13th, the White Sox narrowly won against the Royals, 6-5. Colson Montgomery had a strong performance, hitting 3 for 4 with a home run. The team hit well with 10 hits and managed to hold off the Royals despite some challenges on the mound.

BTB Betting Pick

The Cubs are favored on the moneyline at -113 against the White Sox at -106. The Cubs have a slightly better batting average and on-base percentage. Their pitching also ranks higher in ERA and batting average against. The Cubs’ overall stats suggest they have the edge, so the pick is the Cubs to win straight up.

The total for the game is set at 8.5 runs, with the over at -113 and the under at -108. The Cubs have a solid pitching staff, with a 3.80 ERA, while the White Sox have a higher ERA of 4.35. Given these stats, a low-scoring game seems likely, making the under 8.5 runs the pick.