Charlotte 49ers vs South Florida Bulls Betting Pick & Prediction for 10/3

College Football Preview

In Week 6 of the 2025 season, the Charlotte 49ers travel to Tampa to take on the South Florida Bulls. The game will be held at Raymond James Stadium, an outdoor venue. Fans can catch the action on ESPN2 at 7:00 PM on Friday, October 3.

The Charlotte 49ers enter the game with a 1-3 record. They have yet to win on the road this season. Meanwhile, the South Florida Bulls hold a 3-1 record and are unbeaten at home. Both teams compete in the American Conference, adding an extra layer of excitement to this matchup.

Charlotte Team Preview

The Charlotte 49ers have had a mixed start to their 2025 season. They have one win against the Monmouth Hawks, where they scored 42 points. However, they faced losses against Appalachian State, North Carolina, and Rice. The team has shown strength in passing but struggled with rushing yards.

Quarterback Conner Harrell has been a key player with 737 passing yards over four games. Unfortunately, Harrell is out for the rest of the season due to a knee injury. This means the team will rely more on Grayson Loftis, who has 296 passing yards in three games. The 49ers have also seen strong performances from wide receiver E. Jai Mason with 308 receiving yards and three touchdowns.

The team faces injury challenges, with several players questionable or out for the season. Running back Henry Rutledge is out with a lower body injury. Offensive linemen and key defensive players are also facing uncertainties. Despite these setbacks, Charlotte aims to improve its performance in the coming games.

Charlotte vs South Florida Game Day Info

  • Sport: NCAA Football
  • Teams: Charlotte 49ers vs. South Florida Bulls
  • Venue: Raymond James Stadium in Tampa, FL
  • Date: Friday, October 3, 2025
  • Betting Odds: Charlotte +1922, South Florida -7089

South Florida Team Preview

The South Florida Bulls had an impressive win against the South Carolina State Bulldogs with a score of 63-14. They gained 252 yards both in passing and rushing. Despite having fewer first downs than the Bulldogs, the Bulls controlled the game at Raymond James Stadium.

Earlier in the season, the Bulls faced a tough game against the Miami Hurricanes, losing 49-12. In that game, they managed 292 passing yards but only 40 rushing yards. The defense struggled, allowing 205 rushing yards to the Hurricanes.

The Bulls secured a close win against the Florida Gators with a score of 18-16. They matched the Gators with 20 first downs and threw for 263 passing yards. Their defense played a key role by not allowing any interceptions.

BTB Betting Pick

The Charlotte 49ers are facing a large spread of +28.0 against South Florida. With Charlotte’s offense ranked 84th in points and South Florida’s defense ranked 54th in points allowed, the gap may not be as wide as the spread suggests. The pick is for Charlotte to cover the +28.0 spread, with a projected score of South Florida 35, Charlotte 14.

The total for the game is set at 55.0. Charlotte has scored 73 points this season, while South Florida has scored 127 points. Considering both teams’ scoring and defensive stats, the pick is to go under the total of 55.0, with a projected total of 49 points.