Buffalo Bills vs Houston Texans Betting Pick & Prediction for 11/20

NFL Game preview

The Buffalo Bills travel to Houston to take on the Texans in Week 12 of the 2025 NFL season. This Thursday night game is set to kick off at 8:15 PM at NRG Stadium. The Bills come into the game with a 7-3 record, while the Texans hold a 5-5 record.

Buffalo has been strong at home with a 5-1 record, but their road performance stands at 2-2. Houston, on the other hand, has a 3-2 record at home. The game will be broadcast on AMZN, and with the retractable roof at NRG Stadium, weather should not be a factor. The odds favor Buffalo with a moneyline of -280, while Houston is at +228.

Buffalo Bills Team Preview

The Buffalo Bills have a strong quarterback in Josh Allen. In 2025, he has thrown for 2,456 yards and 18 touchdowns. His passing yards rank him 9th in the league, and he is top for his team.

James Cook leads the running backs with 968 rushing yards. He has scored seven rushing touchdowns, ranking 6th in the league. Cook also contributes with 190 receiving yards on 21 receptions.

Khalil Shakir stands out among the wide receivers. He has made 46 receptions for 454 yards and three touchdowns. He is the top receiver for the Bills, showing his importance to their offense.

Bills vs Texans Game Day Info

  • Sport: NFL
  • Teams: Buffalo Bills vs. Houston Texans
  • Venue: NRG Stadium in Houston, TX USA
  • Date: Thursday, November 20, 2025
  • Betting Odds: Bills Moneyline -280, Texans Moneyline +228, Bills Spread -6.0 (-108), Texans Spread +6.0 (-111), Total Over 43.5 (-111), Total Under 43.5 (-109)

Houston Texans Team Preview

The Houston Texans have shown strong performances in their recent games. In Week 11, they edged out the Tennessee Titans with a 16-13 win. The Texans had a solid game, gaining 240 passing yards and 75 rushing yards, while not committing any fumbles or interceptions.

In Week 10, the Texans secured a 36-29 victory against the Jacksonville Jaguars. Their offense was impressive, recording 282 passing yards and 130 rushing yards. Davis Mills led the team with two passing touchdowns, supported by key plays from Nico Collins and Woody Marks.

However, in Week 9, the Texans faced a narrow 18-15 loss to the Denver Broncos. Their offense struggled a bit, with only 191 passing yards and 77 rushing yards. Dalton Schultz was a standout player, contributing 77 receiving yards in the game.

BTB Betting Pick

The Buffalo Bills are favored by 6 points against the Houston Texans. With the Bills’ strong offense, ranked 2nd in scoring, they are expected to cover the spread. The projected score is Bills 28, Texans 20, making the Bills the pick to cover the -6 spread.

The total for the game is set at 43.5 points. The combined projected score is 48 points, suggesting the over is the better choice. Both teams have offenses capable of scoring, and the defenses may allow enough points to push the total over the line.