Baltimore Orioles vs Boston Red Sox Betting Pick & Prediction for Game on 7/22

MLB game preview

The Baltimore Orioles are set to play the Boston Red Sox in an MLB regular season game. The Orioles come into this game with a record of 49-52. They are ranked fourth in the AL East and have won seven of their last ten games. Manager Craig Albernaz will look to improve their 21-27 road record.

Meanwhile, the Boston Red Sox are on a hot streak, having won their last 14 games. With a record of 51-48, they hold the third spot in the AL East. Interim Manager Chad Tracy will aim to continue their winning ways at Fenway Park. The game will take place on Wednesday, July 22, 2026, at 7:10 PM, and it will be broadcast on MASN.

Baltimore Orioles Team Preview

The Baltimore Orioles have had a mixed performance in recent games. They lost to the Boston Red Sox 6-5 on July 20th, but they collected 11 hits. Shane Baz, the starting pitcher, threw for 6 innings with 2 earned runs and 6 strikeouts.

In the series against the Houston Astros, the Orioles won three games. On July 19th, they won 5-2 with Brandon Young pitching 7 innings and allowing only 1 earned run. Coby Mayo had a strong performance, hitting a home run in that game.

For the upcoming game, Kyle Bradish is set to start for the Orioles. This season, Bradish has a 6-9 record with a 3.61 ERA. The team has been relying on key players like Pete Alonso, who leads in home runs and RBIs.

Orioles vs Red Sox Game Day Info

  • Sport: MLB
  • Teams: Baltimore Orioles vs. Boston Red Sox
  • Venue: Fenway Park in Boston, MA
  • Date: Wednesday, July 22, 2026
  • Betting Odds: Orioles Moneyline +135, Red Sox Moneyline -160, Orioles Runline +1.5 (-145), Red Sox Runline -1.5 (+120), Total Over 8.5 (-125), Total Under 8.5 (+105)

Boston Red Sox Team Preview

The Boston Red Sox are on a winning streak, taking five straight games. They recently had a close win against the Baltimore Orioles, with a final score of 6-5. Willson Contreras played a key role, going 3-for-4 with two RBIs.

The team’s batting average this season is .245, ranking them 11th in the league. Willson Contreras leads the team with a .289 batting average and 22 home runs. Caleb Durbin and Wilyer Abreu also contribute significantly with 10 and 15 home runs, respectively.

On the pitching side, the Red Sox have a team ERA of 3.55, placing them 4th in the league. Their pitching staff includes Sonny Gray, who had a strong recent performance against the Tampa Bay Rays. The Red Sox are yet to announce their starting pitcher for the upcoming game against the Orioles.

BTB Betting Pick

The Red Sox are favored to win with a moneyline of -160, while the Orioles are at +135. The Red Sox have a stronger pitching staff with a 3.55 ERA, ranking 4th in the league. Given their pitching advantage and home field, the pick is for the Red Sox to win the game.

The total line is set at 8.5 runs, with the over at -125 and the under at +105. The Red Sox pitching is solid, and the Orioles’ batting average is .238, ranked 16th. With these factors, the projected score is low, making the pick for the game to go under 8.5 runs.